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Gibco™ Human HGF Recombinant Protein, PeproTech®

Catalog No. p-7246143
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Quantity:
10 μg
100 μg
2 μg
2 x 250 μg
250 μg
4 x 250 μg
50 μg
Catalog No. Quantity
10039100UG 100 μg
1003910UG 10 μg
1003901M 4 x 250 μg
10039500 2 x 250 μg
10039250UG 250 μg
100392UG 2 μg
10039500UG 2 x 250 μg
1003950UG 50 μg
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Catalog No. 10039100UG

Supplier: Gibco™ LS10039100UG

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Description

Recombinant Protein

100-39-1MG will be provided as 4 x 250 μg (100-39-250UG). 100-39-500UG will be provided as 2 x 250 μg (100-39-250UG). Recombinant Human HGF is an 80.0 kDa polypeptide consisting of 697 amino acid residues. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms.

Specifications

Accession Number P14210
For Use With (Application) Control, Bioactivity
Formulation Protein with no preservative
Gene ID (Entrez) 3082
Molecular Weight (g/mol) 80 kDa
Name Human HGF
Purification Method Purified
Quantity 100 μg
Source Insect cells
Storage Requirements -20°C
Regulatory Status RUO
Endotoxin Concentration <1 EU/μg
Gene Alias C230052L06Rik; DFNB39; Fibroblast derived tumor cytotoxic factor; fibroblast-derived tumor cytotoxic factor; F-TCF; hepatocyte growth factor; Hepatocyte growth factor (hepapoietin A; hepatocyte growth factor (hepapoietin A; scatter factor); Hepatocyte growth factor alpha chain; Hepatocyte growth factor beta chain; Hepatopoeitin A; hepatopoeitin-A; HepatopoietinA; hepatopoietin-A; Hgf; HGF/SF; HGFB; HPTA; Lung fibroblast derived mitogen; lung fibroblast-derived mitogen; NK1; NK2; Scatter factor; scatter factor); SF; SF/HGF
Common Name HGF
Gene Symbol Hgf
Biological Activity Determined by the dose-dependent stimulation of the proliferation of monkey 4 MBr-5 cells. The expected ED50 for this effect is 1.0-20.0 ng/ml
Product Type Protein
Conjugate Unconjugated
Recombinant Recombinant
Sequence Alpha chain: QRKRRNTIHE FKKSAKTTLI KIDPALKIKT KKVNTADQCA NRCTRNKGLP FTCKAFVFDK ARKQCLWFPF NSMSSGVKKE FGHEFDLYEN KDYIRNCIIG KGRSYKGTVS ITKSGIKCQP WSSMIPHEHS FLPSSYRGKD LQENYCRNPR GEEGGPWCFT SNPEVRYEVC DIPQCSEVEC MTCNGESYRG LMDHTESGKI CQRWDHQTPH RHKFLPERYP DKGFDDNYCR NPDGQPRPWC YTLDPHTRWE YCAIKTCADN TMNDTDVPLE TTECIQGQGE GYRGTVNTIW NGIPCQRWDS QYPHEHDMTP ENFKCKDLRE NYCRNPDGSE SPWCFTTDPN IRVGYCSQIP NCDMSHGQDC YRGNGKNYMG NLSQTRSGLT CSMWDKNMED LHRHIFWEPD ASKLNENYCR NPDDDAHGPW CYTGNPLIPW DYCPISRCEG DTTPTIVNLD HPVISCAKTK QLR. Beta chain: VVNGIPTRTN IGWMVSLRYR NKHICGGSLI KESWVLTARQ CFPSRDLKDY EAWLGIHDVH GRGDEKCKQV LNVSQLVYGP EGSDLVLMKL ARPAVLDDFV STIDLPNYGC TIPEKTSCSV YGWGYTGLIN YDGLLRVAHL YIMGNEKCSQ HHRGKVTLNE SEICAGAEKI GSGPCEGDYG GPLVCEQHKM RMVLGVIVPG RGCAIPNRPG IFVRVAYYAK WIHKIILTYK VPQS.
Content And Storage -20°C
Activity Determined by the dose-dependent stimulation of the proliferation of monkey 4MBr-5 cells. The expected ED50 for this effect is 1.0-20.0 ng/ml.
Expression System Insect cells
Form Lyophilized
Purity or Quality Grade ≥98% by SDS-PAGE gel and HPLC analyses.
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