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Gibco™ Human FGF-10 Recombinant Protein, PeproTech®
Recombinant Protein
Supplier: Gibco™ 1002601M
Description
100-00CC-500UG will be provided as 2 x 250 μg (100-00CC-250UG). Recombinant Human FGF-10 is a 19.3 kDa protein consisting of 170 amino acid residues. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
FGF10 is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of lim bud formation. This protein is also implicated to be a primary factor in the process of wound healing.Specifications
| O15520 | |
| Protein with no preservative | |
| 19.3 kDa | |
| Purified | |
| E. coli | |
| RUO | |
| AEY17; BB213776; FGF; Fgf10; FGF-10; Fibroblast growth factor; Fibroblast growth factor 10; Gsfaey17; Keratinocyte growth factor 2; produced by fibroblasts of urinary bladder lamina propria | |
| FGF10 | |
| Protein | |
| Recombinant | |
| -20°C | |
| E. coli | |
| ≥ 95% by SDS-PAGE gel and HPLC analyses. |
| Control, Western Blot Control, Bioactivity | |
| 2255 | |
| Human FGF-10 | |
| 2 x 500 μg | |
| -20°C | |
| <1 EU/μg | |
| FGF10 | |
| Assay 1: The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF receptors is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 10^6 units/mg Assay 2: Determined by a cell proliferation assay using 4 MBr-5 cells. The expected ED50 for this effect is 0.5-15.0 ng/ml | |
| Unconjugated | |
| MLGQDMVSPE ATNSSSSSFS SPSSAGRHVR SYNHLQGDVR WRKLFSFTKY FLKIEKNGKV SGTKKENCPY SILEITSVEI GVVAVKAINS NYYLAMNKKG KLYGSKEFNN DCKLKERIEE NGYNTYASFN WQHNGRQMYV ALNGKGAPRR GQKTRRKNTS AHFLPMVVHS | |
| Assay 1: The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF receptors is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 10^6 units/mg. Assay 2: Determined by a cell proliferation assay using 4MBr-5 cells. The expected ED50 for this effect is 0.5-15.0 ng/ml. | |
| Lyophilized |