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Invitrogen™ Human FBXW2 (aa 387-454) Control Fragment Recombinant Protein
Description
Highest antigen sequence indentity to the following orthologs: Mouse (99%), Rat (99%). This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-64343. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats.
Specifications
Specifications
| Accession Number | Q9UKT8 |
| Concentration | ≥5.0 mg/mL |
| For Use With (Application) | Neutralization, Control |
| Formulation | PBS, 1M urea with no preservative; pH 7.4 |
| Gene ID (Entrez) | 26190 |
| Name | Human FBXW2 (aa 387-454) Control Fragment |
| pH Range | 7.4 |
| Purification Method | Purified |
| Quantity | 100 μL |
| Storage Requirements | -20°C, Avoid Freeze/Thaw Cycles |
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