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Invitrogen™ Human Factor XII Native Protein

Catalog No. PIRP43076
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100 μg
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Catalog No. Quantity
PIRP43076 100 μg
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Catalog No. PIRP43076 Supplier Invitrogen™ Supplier No. RP43076
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Description

Native Protein

RP-43076 contains native human Factor XII protein. RP-43076 may be used as a positive control in many immunological assays. The product is of human blood/plasma origin. Although the starting material was tested prior to initiation of the manufacturing process, and was found negative or nonreactive for anti-HIV-1/2, HIV-1 antigen(s), HBsAg, STS, anti-HCV, anti-HBcore and anti-HTLV I & II, extreme caution should be used when handling this material as there is a margin of error in all tests. This product is to be used for IN VITRO research purposes only, and is not intended for clinical or diagnostic use!.

This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged.

Specifications

Accession Number P00748
Concentration 2.6 mg/mL
For Use With (Application) Neutralization
Formulation 4mM sodium acetate with 50% glycerol, 150mM NaCl and no preservative; pH 5.3
Gene ID (Entrez) 2161
Molecular Weight (g/mol) 80 kDa
Name Human Factor XII
pH Range 5.3
Purification Method SDS-PAGE
Quantity 100 μg
Source Human
Storage Requirements -20°C, Avoid Freeze/Thaw Cycles
Regulatory Status RUO
Gene Alias beta-factor XIIa part 1; Beta-factor XIIa part 2; coagulation factor XII; coagulation factor XII (Hageman factor); coagulation factor XIIa heavy chain; Coagulation factor XIIa light chain; F12; F13; Factor 12; factor XII; Factor12; FXII; HAE3; HAEX; HAF; hageman factor
Common Name Factor XII
Gene Symbol F12
Product Type Protein
Conjugate Unconjugated
Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Form Liquid
Protein Subtype Native
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