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Gibco™ Human Epiregulin Recombinant Protein, PeproTech® 
Recombinant Protein
Supplier: Gibco™ 10004500UG
Description
Recombinant Human Epiregulin is a 5.6 kDa monomeric protein, containing 50 amino residues, which corresponds to the mature secreted Epiregulin sequence. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
Epiregulin is an EGF-related growth factor that binds specifically to EGFR (ErbB1) and ErbB4, but not ErbB2 or ErbB3. It is expressed mainly in the placenta and peripheral blood leukocytes, as well as in certain carcinomas of the bladder, lung, kidney and colon. Epiregulin stimulates the proliferation of keratinocytes, hepatocytes, fibroblasts and vascular smooth muscle cells. It also inhibits the growth of several tumor-derived epithelial cell lines. Human Epiregulin is initially synthesized as a glycosylated 19.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce a 6.0 kDa mature secreted sequence.Specifications
| O14944 | |
| protein with no preservative | |
| 5.6 kDa | |
| 500 μg | |
| RUO | |
| Ep; Epiregulin; EPR; ER; EREG; Proepiregulin | |
| Ereg | |
| Unconjugated | |
| MVAQVSITKC SSDMNGYCLH GQCIYLVDMS QNYCRCEVGY TGVRCEHFFL | |
| E. coli | |
| ≥ 98% by SDS-PAGE gel and HPLC analyses. |
| Functional Assay | |
| 2069 | |
| Human Epiregulin | |
| E. coli | |
| <1 EU/ μg | |
| Epiregulin | |
| The ED50 was determined by the dose-dependent stimulation of the proliferation of murine Balb/3T3 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 10^5 units/mg | |
| Recombinant | |
| -20°C | |
| Lyophilized |