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Gibco™ Human Epiregulin, Animal-Free Recombinant Protein, PeproTech®

Catalog No. AF10004100
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100 μg
25 μg
500 μg
1 mg
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Catalog No. Quantity
AF10004100 100 μg
AF100041MG 1 mg
AF1000425UG 25 μg
AF10004500 500 μg
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Catalog No. AF10004100 Supplier Gibco™ Supplier No. AF10004100UG
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Description

Recombinant Protein

Recombinant Human Epiregulin is a 5.6 kDa monomeric protein, containing 50 amino residues, which corresponds to the mature secreted Epiregulin sequence. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Epiregulin is an EGF-related growth factor that binds specifically to EGFR (ErbB1) and ErbB4, but not ErbB2 or ErbB3. It is expressed mainly in the placenta and peripheral blood leukocytes, as well as in certain carcinomas of the bladder, lung, kidney and colon. Epiregulin stimulates the proliferation of keratinocytes, hepatocytes, fibroblasts and vascular smooth muscle cells. It also inhibits the growth of several tumor-derived epithelial cell lines. Human Epiregulin is initially synthesized as a glycosylated 19.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce a 6.0 kDa mature secreted sequence.

Specifications

Accession Number O14944
For Use With (Application) Functional Assay
Formulation protein with no preservative
Gene ID (Entrez) 2069
Molecular Weight (g/mol) 5.6 kDa
Name Human Epiregulin, Animal-Free
Quantity 100 μg
Source E. coli
Regulatory Status RUO
Endotoxin Concentration <0.1 EU/ μg
Gene Alias Ep; Epiregulin; EPR; ER; EREG; Proepiregulin
Common Name Epiregulin
Gene Symbol Ereg
Biological Activity Determined by its ability to stimulate the proliferation of mouse Balb/3T3 cells. The expected ED50 is = 0.2 ng/ml, corresponding to a specific activity of = 5 x 10^6 units/mg
Conjugate Unconjugated
Recombinant Recombinant
Sequence MVAQVSITKC SSDMNGYCLH GQCIYLVDMS QNYCRCEVGY TGVRCEHFFL
Content And Storage -20°C
Expression System E. coli
Form Lyophilized
Purity or Quality Grade ≥ 98% by SDS-PAGE gel and HPLC analyses.
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