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Invitrogen™ Human EFHD2 (aa 3-31) Control Fragment Recombinant Protein

Catalog No. RP98470
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100 μL
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RP98470 100 μL
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Catalog No. RP98470 Supplier Invitrogen™ Supplier No. RP98470
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Description

Recombinant Protein

Highest antigen sequence indentity to the following orthologs: Mouse (86%), Rat (86%). This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-61846 (PA5-61846. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.

EFHD2, also known as Swiprosin-1 or SWS1, is an EF-hand and coiled-coil-containing adaptor protein that plays a role in lymphocyte physiology. EFHD2 exhibits the highest expression in CD8+ T cells and immature B cells. It provides a membrane scaffold that is required for the Syk-, SLP-65-, and PLC-gamma2-dependent B-cell receptor (BCR)-induced calcium flux. EFHD2 may also regulate BCR-induced immature and primary B-cell apoptosis. It controls spontaneous apoptosis through the regulation of BCL2L1 abundance. Also, EFHD2 plays a role as negative regulator of the canonical NF-kappa-B-activating branch.

Specifications

Accession Number Q96C19
Concentration ≥5.0 mg/mL
For Use With (Application) Blocking Assay, Control
Formulation 1 M urea, PBS with no preservative; pH 7.4
Gene ID (Entrez) 79180
Name Human EFHD2 (aa 3-31) Control Fragment
Quantity 100 μL
Regulatory Status RUO
Gene Alias 2600015J22Rik; AA408606; D4Wsu27e; EF hand domain containing 2; EF hand domain family, member D2; EF-hand domain family member D2; EF-hand domain family, member D2; EF-hand domain-containing protein D2; Efhd2; MGC4342; RP3-467K16.3; swiprosin 1; swiprosin-1; Sws1; testicular tissue protein Li 62
Common Name EFHD2
Gene Symbol Efhd2
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Protein Tag His-ABP-tag
Sequence TDELATKLSRRLQMEGEGGGETPEQPGLN
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Expression System E. coli
Form Liquid
Purity or Quality Grade >80% by SDS-PAGE and Coomassie blue staining
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