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Invitrogen™ Human DERL2 (aa 217-239) Control Fragment Recombinant Protein

Catalog No. RP101113
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100 μL
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Catalog No. Quantity
RP101113 100 μL
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Catalog No. RP101113 Supplier Invitrogen™ Supplier No. RP101113
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Description

Recombinant Protein

Highest antigen sequence indentity to the following orthologs: Mouse (100%), Rat (100%). This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-61845 (PA5-61845. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.

Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In contrast to DERL1, it is not involved in the degradation of MHC class I heavy chains following infection by cytomegaloviruses. May play a role in cell proliferation.

Specifications

Accession Number Q9GZP9
Concentration ≥5.0 mg/mL
For Use With (Application) Blocking Assay, Control
Formulation 1 M urea, PBS with no preservative; pH 7.4
Gene ID (Entrez) 51009
Name Human DERL2 (aa 217-239) Control Fragment
Quantity 100 μL
Regulatory Status RUO
Gene Alias carcinoma related; CGI-101; Degradation in endoplasmic reticulum protein 2; Der1-like domain family, member 2; der1-like protein 2; Der2; Derl2; derlin 2; derlin-2; derlin-2-like; DERtrin-2; F-LAN-1; Flana; F-LANa; LOC100910823; SBBI53
Common Name DERL2
Gene Symbol DERL2
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Protein Tag His-ABP-tag
Sequence NYNPLPEERPGGFAWGEGQRLGG
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Expression System E. coli
Form Liquid
Purity or Quality Grade >80% by SDS-PAGE and Coomassie blue staining
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