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Invitrogen™ Human Cyr61/CCN1 ELISA Kit
Description
Human Cyr61/CCN1 quantitates human Cyr61/CCN1 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human Cyr61/CCN1.
CYR61 is a secreted heparin binding protein, encoded by a growth factor inducible immediate-early gene that associates with the extracellular matrix and connective tissue. CYR61 is a member of a distinct family of angiogenic and vasculogenic regulators designated CCN proteins, which includes connective tissue growth factor (CTGF) and the mouse CYR61 homolog, Fisp12. As an angiogenic inducer, CYR61 binds to the cell surface receptor integrin alphavbeta3, where it then stimulates cell adhesion and migration and promotes DNA synthesis of human vascular endothelial cells. Expression of CYR61 is elevated during vessel growth, wound healing and chondrocyte differentiation. CYR61 is also detected in a wide variety of tumors as it induces tumor growth and functions as a marker of tumor progression.
Specifications
Specifications
| Accession Number | 3 CH61; AI325051; CCN family member 1; Ccn1; Cellular communication network factor 1; Cyr61; cysteine rich angiogenic inducer 61; cysteine rich protein 61; cysteine rich protein 61-like; cysteine-rich angiogenic inducer 61; cysteine-rich heparin-binding protein 61; cysteine-rich, angiogenic inducer, 61; cysteine-rich, anigogenic inducer, 61; GIG1; IBP-10; IGF-binding protein 10; IGFBP10; IGFBP-10; insulin-like growth factor binding protein 10; insulin-like growth factor-binding protein 10; intermediate early; LOC100339657; protein CYR61; Protein GIG1 |
| Assay Range | 0.137 to 100 ng/mL |
| Assay Sensitivity | 0.13 ng/mL |
| Conjugate | HRP |
| Product Type | ELISA |
| Sample Type | Plasma, Serum, Supernatant |
| For Use With (Equipment) | Colorimetric Microplate Reader |
| Gene ID (Entrez) | 3491 |
| Gene Symbol | CCN1 |
| Interassay CV | <12% |
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