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Gibco™ Human BTLA Fc Recombinant Protein, PeproTech®

Catalog No. 3104350UG
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Catalog No. Quantity
3104350UG 50 μg
31043100UG 100 μg
3104310UG 10 μg
310431MG 1 mg
31043250UG 250 μg
31043500UG 500 μg
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Catalog No. 3104350UG Supplier Gibco™ Supplier No. 3104350UG

Description

Recombinant Protein

PeproTech's CHO cell-derived Recombinant Human BTLA Fc is a glycosylated, disulfide-linked homodimer of 353-amino-acid-residues whose monomer consists of a 120-amino-acid portion of the extracellular domain fused to the 231-amino-acid length Fc portion of human IgG by two glycine residues. The calculated molecular weight of monomeric CHO cell-derived Recombinant Human BTLA Fc is 39.8 kDa; however, due to glycosylation, it migrates at an apparent molecular weight of approximately 50-55 kDa by SDS-PAGE analysis under reducing conditions. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

BTLA or B and T-lymphocyte attenuator is a member of the co-inhibitory receptors of the CD28 superfamily. BTLA is a lymphocyte inhibitory receptor which inhibits lymphocytes during immunes responses. BTLA is constitutively expressed on most CD4+ and CD8+ T cells and its expression progressively decreases upon T cell activation. It remains expressed on Th1 cells, but not Th2 cells. BTLA is a unique co-receptor that interacts with the tumor necrosis factor receptor superfamily member herpesvirus entry mediator (HVEM). This interation is an important pathway regulating lymphocyte activation and/or homeostasis in the immune response.

Specifications

Accession Number Q7Z6A9
For Use With (Application) Control, ELISA Standard, Binding Assay
Formulation Protein with no preservative
Gene ID (Entrez) 151888
Molecular Weight (g/mol) 39.8 kDa
Name Human BTLA Fc
Purification Method Purified
Quantity 50 μg
Source CHO cells
Storage Requirements -20°C
Regulatory Status RUO
Endotoxin Concentration <1 EU/μg
Gene Alias A630002H24; B and T lymphocyte associated; B and T lymphocyte associated protein; B and T lymphocyte attenuator; B- and T-lymphocyte attenuator; B- and T-lymphocyte-associated protein; BTLA; BTLA_HUMAN; BTLA1; CD272; CD272 antigen; FLJ16065; MGC129743
Common Name BTLA (CD272)
Gene Symbol BTLA
Biological Activity Determined by its ability to bind recombinant Murine HVEM Fc in a functional ELISA.
Product Type Protein
Conjugate Unconjugated
Recombinant Recombinant
Protein Tag Fc-tag
Sequence KESCDVQLYI KRQSEHSILA GDPFELECPV KYCANRPHVT WCKLNGTTCV KLEDRQTSWK EEKNISFFIL HFEPVLPNDN GSYRCSANFQ SNLIESHSTT LYVTDVKSAS ERPSKDEMAS GGPKSCDKTH TCPPCPAPEL LGGPSVFLFP PKPKDTLMIS RTPEVTCVVV DVSHEDPEVK FNWYVDGVEV HNAKTKPREE QYNSTYRVVS VLTVLHQDWL NGKEYKCKVS NKALPAPIEK TISKAKGQPR EPQVYTLPPS RDELTKNQVS LTCLVKGFYP SDIAVEWESN GQPENNYKTT PPVLDSDGSF FLYSKLTVDK SRWQQGNVFS CSVMHEALHN HYTQKSLSLS PGK
Content And Storage -20°C
Activity Determined by its ability to bind recombinant Murine HVEM Fc in a functional ELISA.
Expression System CHO cells
Form Lyophilized
Purity or Quality Grade ≥ 95% by SDS-PAGE gel and HPLC analyses.
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