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Gibco™ Human Artemin, Animal-Free Recombinant Protein, PeproTech®

Numéro de catalogue. AF45017250U
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Quantité:
250 μg
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Numéro de catalogue. Quantité
AF45017250U 250 μg
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Numéro de catalogue. AF45017250U Fournisseur Gibco™ Code fournisseur AF45017250UG

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Description

Recombinant Protein

The functional human Artemin ligand is a disulfide-linked homodimer of two 12.0 kDa polypeptide monomers. Each monomer contains seven conserved cysteine residues, one of which is used for interchain disulfide bridging and the others are involved in intramolecular ring formation known as the cysteine-knot configuration.Recombinant Human Artemin is a 24.2 kDa, disulfide-linked homodimer formed by two identical 113 amino acid subunits. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

The protein encoded by this gene is a member of the glial cell line-derived neurotophic factor (GDNF) family of ligands which are a group of ligands within the TGF-beta superfamily of signaling molecules. GDNFs are unique in having neurotrophic properties and have potential use for gene therapy in neurodegenerative disease. Artemin has been shown in culture to support the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. Its role in the PNS and CNS is further substantiated by its expression pattern in the proximity of these neurons. This protein is a ligand for the RET receptor and uses GFR-alpha 3 as a coreceptor. Multiple transcript variants encoding different isoforms have been found for this gene.

Spécifications

Numéro d'enregistrement Q5T4W7
À utiliser avec (application) Control
Format Lyophilized
Formule Protein with no preservative
ID du gène (Entrez) 9048
Poids moléculaire (g/mol) 24.2 kDa
Nom Human Artemin, Animal-Free
Méthode de purification Purified
Quantité 250 μg
Conditions de stockage -20°C
Statut réglementaire RUO
Concentration en endotoxines <0.1 EU/μg
Alias du gène Artemin; ARTN; Enovin; EVN; NBN; neublastin; neurotrophic factor
Nom usuel Artemin
Symbole de gène ARTN
Type de produit Protein
Conjugué Unconjugated
Recombinant Recombinant
Séquence AGGPGSRARA AGARGCRLRS QLVPVRALGL GHRSDELVRF RFCSGSCRRA RSPHDLSLAS LLGAGALRPP PGSRPVSQPC CRPTRYEAVS FMDVNSTWRT VDRLSATACG CLG
Contenu et stockage -20°C
Système d’expression E. coli
Forme Lyophilized
Grade de qualité ou de pureté ≥ 98% by SDS-PAGE gel and HPLC analyses.
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