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Gibco™ Human APRIL Recombinant Protein, PeproTech®
Recombinant Protein
Supplier: Gibco™ 31010C50UG
Description
310-10C-01M will be provided as 20 x 50 μg (310-10C-50UG). 310-10C-500 will be provided as 10 x 50 μg (310-10C-50UG). 310-10C-250 will be provided as 5 x 50 μg (310-10C-50UG). 310-10C-100 will be provided as 2 x 50 μg (310-10C-50UG) Recombinant human APRIL is a soluble 16.3 kDa protein, consisting of 146 amino acid residues. *Human APRIL (Catalog Number 310-10C) has replaced Human APRIL (Catalog Number 310-10). This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated APRIL (for A PRoliferation-Inducing Ligand), TALL2 (for TNF and ApoL-related Leukocyte-expressed Ligand 2), and TRDL 1a (for TNF related death ligand 1a) in human and mouse. Two receptors for APRIL were recently identified and designated TACI and BCMA. APRIL stimulates B and T cell proliferation, triggers humoral immune responses, activates NF-kB, and induces cell death. APRIL and its close relative of BlyS and their receptors BCMA and TACI are involved in diseases of autoimmunity and cancer.Specifications
O75888 | |
protein with no preservative | |
16.3 kDa | |
50 μg | |
RUO | |
2310026N09Rik; A proliferation-inducing ligand; APRIL; CD256; TALL2; TALL-2; TNF- and APOL-related leukocyte expressed ligand 2; TNF-related death ligand 1; Tnfsf13; TNLG7B; Trdl1; TRDL-1; tumor necrosis factor (ligand) superfamily, member 13; tumor necrosis factor ligand 7 B; tumor necrosis factor ligand superfamily member 13; tumor necrosis factor superfamily member 13; tumor necrosis factor-like protein ZTNF2; tumor necrosis factor-related death ligand-1; UNQ383/PRO715; ZTNF2 | |
TNFSF13 | |
Unconjugated | |
AVLTQKQKKQ HSVLHLVPIN ATSKDDSDVT EVMWQPALRR GRGLQAQGYG VRIQDAGVYL LYSQVLFQDV TFTMGQVVSR EGQGRQETLF RCIRSMPSHP DRAYNSCYSA GVFHLHQGDI LSVIIPRARA KLNLSPHGTF LGFVKL | |
Insect cells | |
≥ 95% by SDS-PAGE gel and HPLC analyses. |
Functional Assay | |
8741 | |
Human APRIL | |
Insect cells | |
<1 EU/ μg | |
APRIL | |
Determined by its ability to induce NF-kappaB activation in HEK293-NF-kappaB reporter cells transfected with BCMA receptor. | |
Recombinant | |
-20°C | |
Lyophilized |