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Invitrogen™ HSPB8 Monoclonal Antibody (7D8)
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Catalog No. PIMA549225
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100 μg
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Catalog No. Quantity
PIMA549225 100 μg
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Catalog No. PIMA549225 Supplier Invitrogen™ Supplier No. MA549225
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Description

Mouse Monoclonal Antibody

Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL. Human HSPB8/Hsp22 shares 94.4% and 95.4% amino acid (aa) sequence identity with mouse and rat HSPB8/Hsp22, respectively. Positive Control - WB: human Hela whole cell, human T-47D whole cell, rat RH35 whole cell. ICC/IF: A431 cell. Flow: CACO-2 cell, U20S cell. Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease.

Specifications

Antigen HSPB8
Applications Flow Cytometry, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 7D8
Concentration 500 μg/mL
Conjugate Unconjugated
Formulation PBS with 4mg trehalose and 0.05mg sodium azide
Gene HSPB8
Gene Accession No. Q9EPX0, Q9UJY1
Gene Alias Alpha-crystallin C chain; AU018630; AW413033; CMT2L; Cryac; crystallin, alpha C; D5Ucla4; DHMN 2; DHMN2; E2IG1; E2-induced gene 1 protein; H11; H11K; heat shock 22kDa protein 8; heat shock 27kDa protein 8; Heat shock protein; heat shock protein 8; heat shock protein B8; heat shock protein beta-8; heat shock protein family B (small) member 8; HMN 2; HMN2; HMN2A; HSB8; HSP; HSP20-like; Hsp22; HSPB 8; Hspb8; OTTHUMP00000239768; PP1629; Protein kinase H11; small stress protein-like protein HSP22
Gene Symbols HSPB8
Host Species Mouse
Immunogen E.coli-derived human HSPB8/Hsp22 recombinant protein (Position: M1-T196).
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 113906, 26353
Target Species Human, Rat
Content And Storage -20°C
Product Type Antibody
Form Lyophilized
Isotype IgG2b
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