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Invitrogen™ HIP55 Polyclonal Antibody
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Catalog No. PIPA589408
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100 μL
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PIPA589408 100 μL
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Catalog No. PIPA589408 Supplier Invitrogen™ Supplier No. PA589408
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: KVAKASGANY SFHKESGRFQ DVGPQAPVGS VYQKTNAVSE IKRVGKDSFW AKAEKEEENR RLEEKRRAEE AQRQLEQERR ERELREAARR EQRYQEQGGE ASPQRTWEQQ QEVVSRNRNE QESAVHPREI FKQKERAMST TSISSPQPGK LRSPFLQKQL TQPETHFGRE PAAAISRPRA DLPAEEPAPS TPPCLVQAEE EAVYEEPPEQ ETFYEQPPLV QQQGAGSEHI DHHIQGQGLS GQGLCARALY DYQAADDTEI SFDPENLITG IEVIDEGWWR GYGPDGHFGM FPANYVELIE; Positive Samples: HeLa, MCF-7, Jurkat, K-562, Mouse brain, Mouse thymus, Mouse spleen, Mouse testis, Rat heart; Cellular Location: Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoplasmic side, Cytoplasmic vesicle, Golgi apparatus membrane, Peripheral membrane protein, cell cortex, clathrin-coated vesicle membrane, cytoskeleton, cytosol, lamellipodium, podosome, ruffle, synapse.

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported.

Specifications

Antigen HIP55
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 2.72 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene DBNL
Gene Accession No. Q62418, Q9JHL4, Q9UJU6
Gene Alias Abp1; Actin-binding protein 1; cervical mucin-associated protein; Cervical SH3P7; CMAP; DBNL; dbnl {ECO:0000312; drebrin F; drebrin like; drebrin-F; drebrin-like; drebrin-like protein; EMBL:AAH72483.1}; HIP55; HIP-55; HPK1-interacting protein of 55 kDa; mAbp1; PP5423; SH3 domain-containing protein 7; Sh3p7; src homology 3 domain-containing protein HIP-55
Gene Symbols DBNL
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 131-430 of human DBNL (NP_0010144361).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 13169, 28988, 83527
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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