Invitrogen™ Hepatitis B Virus X Monoclonal Antibody (X36C)

Description

MA1-081 detects hepatitis B x (HBx) protein from transfected human cells. MA1-081 has been successfully used in Western blot, immunoprecipitation and ELISA procedures. By Western blot, this antibody detects a single ~17 kDa protein representing HBx. This antibody is not capable of immunoprecipitating HBx complexed with HBx interacting protein (XIP). The MA1-081 immunogen is baculovirus expressed recombinant HBx.

The hepatitis B virus is an important cause of acute and chronic liver disease. It is also the most common form of parenterally transmitted viral hepatitis. The Hepatitis B X antigen is a 154 amino acid ~17 kDa multifunctional protein involved in the development of liver chirrosis and hepatocellular carcinoma. The virus is estimated to affect some 350 million people worldwide. Immunization against hepatitis B is an important component of preventative medicine and is offered to all children in approximately 30 countries. Hepatitis B virus (HBV) belongs to the Hepadnaviridae family and infection with HBV is usually more serious than infection with hepatitis A virus. In some individuals the infection is not cleared and followed by persistent intracellular viral carriage that can lead to the development of hepatocelular carcinomas. There are currently 400 million HBV carriers worldwide making HBV one of the most common human pathogens.