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Geldanamycin, 98+%
Benzoquinoid antibiotic that inhibits pp60src tyrosine kinase | CAS: 30562-34-6 | C29H40N2O9 | 560.644 g/mol
$372.56 - $870.48
Chemical Identifiers
| CAS | 30562-34-6 |
|---|---|
| Molecular Formula | C29H40N2O9 |
| Molecular Weight (g/mol) | 560.644 |
| MDL Number | MFCD00274570 |
| InChI Key | QTQAWLPCGQOSGP-KDFVLELPSA-N |
| Synonym | NSC 122750; U-29135 |
| PubChem CID | 133688416 |
| IUPAC Name | [(3S,5R,6S,7R,8Z,11R,14E)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate |
| SMILES | CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)OC)C)OC)OC(=O)N)C)C)O)OC |
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
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AAJ63397MB
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N/A | 25 mg |
Each for $372.56
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AAJ63397MC
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N/A | 100 mg |
Each for $677.23
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AAJ63397MD
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N/A | 250 mg |
Each for $870.48
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Description
Geldanamycin binds to and inhibits the cytosolic chaperone functions of heat shock protein 90 (HSP90). HSP90 maintains the stability and functional shape of many oncogenic signaling proteins. It interferes with conformational maturation of proteins and the cellular stress response. In addition, it is a potent inhibitor of the nuclear hormone receptor family.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
ApplicationsGeldanamycin binds to and inhibits the cytosolic chaperone functions of heat shock protein 90 (HSP90). HSP90 maintains the stability and functional shape of many oncogenic signaling proteins. It interferes with conformational maturation of proteins and the cellular stress response. In addition, it is a potent inhibitor of the nuclear hormone receptor family.
Solubility
Soluble in dimethyl sulfoxide at 100 mg/mL.
Notes
Store in a cool dry place. Keep away from oxidizing agents. Protect from heat.
Chemical Identifiers
| 30562-34-6 | |
| 560.644 | |
| QTQAWLPCGQOSGP-KDFVLELPSA-N | |
| 133688416 | |
| CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)OC)C)OC)OC(=O)N)C)C)O)OC |
| C29H40N2O9 | |
| MFCD00274570 | |
| NSC 122750; U-29135 | |
| [(3S,5R,6S,7R,8Z,11R,14E)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate |
Specifications
| Geldanamycin | |
| 30562-34-6 | |
| C29H40N2O9 | |
| NSC 122750; U-29135 | |
| QTQAWLPCGQOSGP-KDFVLELPSA-N | |
| [(3S,5R,6S,7R,8Z,11R,14E)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate | |
| 133688416 | |
| ≥99% |
| Powder | |
| Orange to Yellow | |
| MFCD00274570 | |
| Soluble in dimethyl sulfoxide at 100mg/mL. | |
| CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)OC)C)OC)OC(=O)N)C)C)O)OC | |
| 560.644 | |
| 560.64 | |
| Geldanamycin |
Safety and Handling
RTECSNumber : LX8920000
TSCA : No
Recommended Storage : Store at -20°C
RUO – Research Use Only