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  6. Invitrogen™ FOXO4 Recombinant Rabbit Monoclonal Antibody (23GB1470)

Invitrogen™ FOXO4 Recombinant Rabbit Monoclonal Antibody (23GB1470)

Catalog No. MA553995
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100 μL
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MA553995 20 μL
MA553994 100 μL
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Catalog No. MA553995 Supplier Invitrogen™ Supplier No. MA553995

Description

Rabbit Recombinant Monoclonal Antibody

FOXO4 Recombinant Monoclonal Antibody for Flow, ICC/IF, Western Blot

FOXO4 (Forkhead box O4) is encoded by the FOXO4 gene located on the X chromosome. It is also known as AFX1 or MLLT7 (Myeloid/Lymphoid or Mixed-Lineage Leukemia (Trithorax Homolog, Translocated To, 7) and is a member of the O class of forkhead/ winged helix family of transcription factors along with FOXO1, FOXO3 and FOXO6. FOXO4 is abundantly expressed in skeletal muscle and adipose tissue. FOXO4 binds to the Insulin Responsive Element (IRE) and activates downstream targets of Insulin/IGF1 signaling such as IGFBP1. However, the activation of another downstream target of the Insulin/IGF1 pathway, Akt, leads to phosphorylation of FOXO4 on specific Ser/Thr residues. This phosphorylation mediates binding of FOXO4 to 14-3-3 and eventual exit of FOXO4 from the nucleus.

Specifications

Antigen FOXO4
Applications Flow Cytometry, Western Blot, Immunocytochemistry
Classification Recombinant Monoclonal
Clone 23GB1470
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene FOXO4
Gene Accession No. P98177, Q9WVH3
Gene Alias AFX; Afx1; Afxh; AFXzeta; Fkhr3; Fork head domain transcription factor AFX1; forkhead box O4; forkhead box protein O4; forkhead protein; FOXO4; FOXO4b; MGC120490; MLLT7; myeloid/lymphoid or mixed lineage-leukemia translocation to 7 homolog; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7; OTTHUMP00000023497; RGD1561201
Gene Symbols FOXO4
Host Species Rabbit
Immunogen A synthesized peptide derived from human FoxO4 (450-505AA).
Purification Method Affinity Chromatography
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 302415, 4303, 54601
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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