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Invitrogen™ FN3KRP Polyclonal Antibody
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Catalog No. PIPA528166
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Catalog No. Quantity
PIPA528166 100 μL
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Catalog No. PIPA528166 Supplier Invitrogen™ Supplier No. PA528166
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: 293T, A431, H1299, HepG2, Molt-4, Raji. Predicted reactivity: Mouse (86%), Rat (86%), Dog (84%), Rhesus Monkey (82%), Bovine (84%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Fructosamine-3-kinase related protein (FN3KRP) is located on chromosome 17q25.3, approximately 8 kb upstream of the FN3K gene. It shares 65% amino acid identity with FN3K and possesses an identical genomic organization, implying functional similarities; FN3KRP is suggested to play a role in enzymatic deglycation. Unlike FN3K, FN3KRP is more ancient, present in diverse organisms such as cyanobacteria, echinoderms, plants, and cold-blooded vertebrates. Studies have discovered a significant association between rs1046896 in FN3KRP and longevity, where the longevity allele C is linked to increased FN3KRP expression in whole blood. FN3KRP is hypothesized to phosphorylate glucitolamines, products of non-enzymatic glycation, indicating its involvement in crucial metabolic processes. The regulation of both FN3K and FN3KRP is notable for TATA-less and CAAT-less promoters, featuring homologous CpG islands and Sp1 binding sites. Meanwhile, both genes are widely expressed across human tissues, but FN3K demonstrates significantly higher levels in tissues prone to glycation-related complications.

Specifications

Antigen FN3KRP
Applications Western Blot
Classification Polyclonal
Concentration 0.57 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
Gene FN3KRP
Gene Accession No. Q9HA64
Gene Alias FN3KL; FN3K-related protein; Fn3krp; FN3K-RP; fructosamine 3 kinase related protein; fructosamine 3-kinase-related protein; fructosamine-3-kinase-related protein; Ketosamine-3-kinase; ortholog of human fructosamine-3-kinase-related protein FN3KRP; Protein-psicosamine 3-kinase FN3KRP; RGD1304570; testis secretory sperm-binding protein Li 211a
Gene Symbols FN3KRP
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human FN3KRP. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 79672
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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