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Invitrogen™ FAM35A/FAM35B Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA5104378
Description
Antibody detects endogenous levels of total FAM35A/B.
Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs) (PubMed:29656893, PubMed:29789392). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection (PubMed:29656893, PubMed:29789392). Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres (PubMed:29656893). [UniProt].Specifications
| FAM35A/FAM35B | |
| Polyclonal | |
| Unconjugated | |
| FAM35A | |
| 3110001K24Rik; bA163M19.1; Fam35a; FAM35A1; family with sequence similarity 35 member A; family with sequence similarity 35, member A; protein FAM35A; RINN1-REV7-interacting novel NHEJ regulator 2; RINN2; Shield complex subunit 2; Shieldin complex subunit 2; SHLD2 | |
| Rabbit | |
| Affinity chromatography | |
| RUO | |
| 54537 | |
| -20°C | |
| Liquid |
| Western Blot, Immunocytochemistry | |
| 1 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.4 | |
| Q86V20 | |
| FAM35A | |
| A synthesized peptide derived from human FAM35A(Accession Q86V20), corresponding to amino acid residues S393-N443. | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |