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Invitrogen™ ERRF Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA555373
Description
Immunogen sequence: HLTRVTPMGG GCLAQARATL PLCRGSVASA SFPVSPLCPQ EVPEAKGKPV KAAPVRSSTW GTVKDSLKAL SSCVCGQ Highest antigen sequence identity to the following orthologs: Mouse - 42%, Rat - 30%.
The estrogen receptor-related factor (ERRF) is a recently identified protein whose expression is upregulated in multiple cell lines and primary breast cancer tumors. Increased ERRF expression was significantly associated with ER or progesterone receptor (PR) positivity even in HER2-negative tumors. This higher ERRF expression correlated with better disease-free survival and overall survival. In two ER-positive breast cancer cell lines, knockdown of ERRF suppressed cell growth in vitro and tumorigenesis in xenograft models, suggesting that ERRF plays a role in estrogen-ER-mediated breast cancer cell growth and may thus be a potential therapeutic target.Specifications
| ERRF | |
| Polyclonal | |
| Unconjugated | |
| SRARP | |
| C1orf64; chromosome 1 open reading frame 64; ER-related factor; ERRF; Gm694; predicted gene 694; RP11-5P18.4; Srarp; SSPR; Steroid receptor-associated and regulated protein; Steroid receptor-regulated protein; uncharacterized protein C1orf64; uncharacterized protein C1orf64 homolog | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 149563 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunohistochemistry (Paraffin), Western Blot | |
| 0.1 mg/mL | |
| PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
| Q8NEQ6 | |
| SRARP | |
| Recombinant protein corresponding to Human ERRF. Recombinant protein control fragment (Product #RP-92440). | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |