Invitrogen™ Epstein Barr Virus p18 Polyclonal Antibody

Description

The PA1-73003 antibody reacts with Epstein-Barr virus p18. PA1-73003 has been successfully used in ELISA and immunofluorescence applications. IHC and WB are potential applications but have not yet been tested. The PA1-73003 antibody was raised against Recombinant EBV p18. Recommended short term storage (<6 months) is at 4°C. For longer term storage, aliquot and freeze.

Epstein-Barr virus (EBV) is a human herpes virus, which is associated with conditions such as Hodgkin's disease and Burkitt's Lymphoma and is the causative agent in mononucleosis in adolescents. EBV latently infects B lymphocytes. Infected B cells express EBV nuclear antigens and latent proteins LMP1, LMP2A and LMP2B. LMP2A forms aggregates in the plasma membranes of B lymphocytes, where it functions as a negative regulator of the Src and Syk protein tyrosine kinases. Studies show that LMP2A blocks B-cell receptor (BCR) signal transduction in EBV immortalized B cells in vitro and may play an important role in maintaining a latent EBV infection within the peripheral blood B cells of infected individuals.EBNA-1 is the only viral protein consistently expressed in all malignancies associated with EBV.