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Enalaprilat

Catalog No. AAJ63392MA
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Quantity:
10 mg
50 mg
Catalog No. Quantity
AAJ63392MA 10 mg
AAJ63392MF 50 mg
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Catalog No. AAJ63392MA

Supplier: Thermo Scientific Chemicals J63392MA

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Description

The active metabolite of enalapril | CAS: 76420-72-9 | C18H24N2O5 | 348.399 g/mol

Enalapril is a ACE (angiotensin-converting enzyme) inhibitor, suggested to be more potent than Captopril (sc-200566). Studies indicate that Enalapril downregulates the expression of IL-β, IL-6, and NF-κB. Further studies show that Enalapril upregulates the expression of VEGF and heme oxygenase-1. Enalaprilat reports demonstrate that the compound has some antioxidant activity, which does not include the PKC-NADPH oxidase pathway.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Enalapril is a ACE (angiotensin-converting enzyme) inhibitor, suggested to be more potent than Captopril (sc-200566). Studies indicate that Enalapril downregulates the expression of IL-β, IL-6, and NF-κB. Further studies show that Enalapril upregulates the expression of VEGF and heme oxygenase-1. Enalaprilat reports demonstrate that the compound has some antioxidant activity, which does not include the PKC-NADPH oxidase pathway.

Solubility
Soluble in water with heating (∼60°C)

Notes
Store in a cool dry place. Keep away from oxidizing agents.

Chemical Identifiers

CAS 76420-72-9
Molecular Formula C18H24N2O5
Molecular Weight (g/mol) 348.399
MDL Number MFCD00865786
InChI Key LZFZMUMEGBBDTC-QEJZJMRPSA-N
Synonym enalaprilat, enalapril acid, enalaprilate, enalaprilatum, enalapril diacid, enalaprilic acid, enalaprilat anhydrous, n-1s-1-carboxy-3-phenylpropyl-l-alanyl-l-proline, unii-q508q118jm
PubChem CID 5462501
ChEBI CHEBI:4786
IUPAC Name (2S)-1-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]propanoyl]pyrrolidine-2-carboxylic acid
SMILES CC(C(=O)N1CCCC1C(=O)O)NC(CCC2=CC=CC=C2)C(=O)O

Specifications

Melting Point 148°C to 151°C
Color White
Quantity 10 mg
Merck Index 14,3568
Solubility Information Soluble in water with heating (∽60°C)
Formula Weight 384.42
Physical Form Crystalline Solid
Chemical Name or Material Enalaprilat

Safety and Handling

EINECSNumber 278-459-3
TSCA No
Recommended Storage Ambient temperatures

RUO – Research Use Only