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MilliporeSigma™ Upstate™ Trimethyl-Histone H3 (Lys4)α, Rabbit Monoclonal, ChIP Validated Antibody and Primer Set
Rabbit Monoclonal Antibody
Supplier: MilliporeSigma™ 17614
Description
Specifically detects Trimethyl-Histone H3 (Lys4)α Clone: in Human, Mammalia, Mouse samples, and it is validated for ChIP, ChIP-seq, Western Blotting
The methylation of histones can occur on two different residues: arginine or lysine. Histone methylation can be associated with transcriptional activation or repression, depending on the methylated residue. Lysine 4 of histone H3 can be mono-, di- or trimethylated by different histone methyltransferases (HMTs) such as SET1 or ASH1. Methylation of Lys4 is often associated with transcriptional activation. The demethylase LSD1 is able to demethylate histone H3 Lys4.Specifications
| Trimethyl-Histone H3 (Lys4)α | |
| Monoclonal | |
| Anti-Trimethyl-Histone H3 (Lys4) recombin-ant rabbit monoclonal IgG. One vial containing 75μL of protein A purified rabbit IgG in storage buffer (0.1M Tris-Glycine pH 7.4, 0.15M NaCl, 0.05% NaN3, with the addition of 40% glycerol. Normal Rabbit IgG. One vial containing 75μL of normal rabbit IgG. Control Primers. One vial containing 75μL of 5μM of each primer specific for human GAPDH. FOR: TAC TAG CGG TTT TAC GGG CG REV: TCG AAC AGG AGG AGC AGA GAG CGA |
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| H3F3A, H3F3B, H3F3 | |
| The trimethyl-histone H3 (Lys4) antibody is made against a BSA-conjugated, synthetic peptide containing the sequence â¦RT[me3K]QT⦠in which me3K corresponds to trimethyl-lysine 4 of human histone H3 | |
| RUO | |
| Primary | |
| Trimethyl-Histone H3 (Lys4) | |
| Human, Mammalia, Mouse | |
| Purified |
| ChIP Assay, ChIP sequencing (ChIP-seq), Western Blot | |
| Unconjugated | |
| Q66I33 | |
| Rabbit | |
| 25 Assays | |
| Epigenetics, Nuclear Function | |
| NM_003493 | |
| Trimethyl-Histone H3 (Lys4) ChIP validated Antibody and Primer set including the ChIP-grade antibody and the specific control PCR primers used for chromatin immunoprecipitation of H3K4Me3. | |
| −20°C for one year from date of shipment | |
| IgG |
For Research Use Only