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Invitrogen™ Human EGFR (ErbB1), GST Tag Recombinant Protein
Description
For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Protein Form: Recombinant, Catalytic Domain, Cytoplasmic.
EGFR, epidermal growth factor receptor, is a receptor tyrosine kinases that signals in response to various growth factors. Overexpression has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics. EGFR is encoded by the EGFR gene located on chromosome 7 in humans. EGFR belongs to the HER/ERbB family of proteins that includes three other receptor tyrosine kinases, ERbB2, ERbB3, ERbB4. EGFR is a transmembrane receptor and binding of its cognate ligands such as EGF (Epidermal Growth Factor) and TGF alpha (Transforming Growth Factor alpha) to the extracellular domain leads to EGFR dimerization followed by autophosphorylation of the tyrosine residues in the cytoplasmic domain. Overexpression is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma.
Specifications
Specifications
| Accession Number | P00533 |
| Concentration | See Label |
| For Use With (Application) | Kinase Assay |
| Formulation | 50mM tris HCl with 0.02% Triton X-100, 50% glycerol, 2mM DTT, 150mM NaCl, 0.5mM EDTA and no preservative; pH 7.5 |
| Gene ID (Entrez) | 1956 |
| Molecular Weight (g/mol) | 90.5 kDa |
| Name | Human EGFR (ErbB1), GST Tag |
| pH Range | 7.5 |
| Purification Method | Purified |
| Quantity | 100 μg |
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