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Invitrogen™ DUT Recombinant Rabbit Monoclonal Antibody (23GB5240)
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Catalog No. MA553872
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100 μL
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MA553872 100 μL
MA553873 20 μL
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Catalog No. MA553872 Supplier Invitrogen™ Supplier No. MA553872
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Description

Rabbit Recombinant Monoclonal Antibody

DUT Recombinant Monoclonal Antibody for Flow, ICC/IF, Western Blot

This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19.

Specifications

Antigen DUT
Applications Flow Cytometry, Western Blot, Immunocytochemistry
Classification Recombinant Monoclonal
Clone 23GB5240
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Dut
Gene Accession No. P33316
Gene Alias 5031412I06Rik; 5133400F09Rik; D2Bwg0749e; Deoxyuridine 5'-triphosphate nucleotidohydrolase; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial; deoxyuridine triphosphatase; Dut; Dutp; dUTP diphosphatase; dUTP nucleotidohydrolase; dUTP pyrophosphatase; dUTPase; FLJ20622; PIP4; PPAR-interacting protein 4
Gene Symbols Dut
Host Species Rabbit
Immunogen A synthesized peptide derived from human DUT (200-252AA).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1854
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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