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Invitrogen™ Doublecortin Monoclonal Antibody (2G5)
Mouse Monoclonal Antibody
Supplier: Invitrogen™ MA517066
Description
MA5-17066 targets DCX in indirect ELISA, FACS, ICC, IHC, IF and WB applications and shows reactivity with Human samples. The MA5-17066 immunogen is purified recombinant fragment of human DCX (amino acids: 362-411) expressed in E. Coli. MA5-17066 detects DCX which has a predicted molecular weight of approximately 49.3kDa.
In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. DCX is a cytoplasmic protein which appears to direct neuronal migration by regulating the organization and stability of microtubules. It contains two doublecortin domains, which bind microtubules. In addition, this protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in the gene encoding DCX are a cause of X-linked lissencephaly.Chemical Identifiers
| Doublecortin | |
| 1 mg/mL | |
| ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry | |
| Unconjugated | |
| Mouse | |
| RUO | |
| PBS with 0.05% sodium azide | |
| O43602 | |
| 1641 | |
| Purified recombinant fragment of human DCX (AA: 362-411) expressed in E. Coli. | |
| Antibody |
| 2G5 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Monoclonal | |
| Liquid | |
| IgG1 | |
| Human | |
| DCX | |
| DBCN; Dbct; DC; Dcn; DCX; doublecortex; doublecortin; doublin; lissencephalin-X; lissencephaly, X-linked (doublecortin); LISX; Lis-X; LIS-XD; Neuronal migration protein doublecortin; OTTHUMP00000023860; OTTHUMP00000216316; SCLH; XLIS | |
| DCX | |
| Primary | |
| Protein G |
Specifications
| Doublecortin | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with 0.05% sodium azide | |
| O43602 | |
| DCX | |
| Purified recombinant fragment of human DCX (AA: 362-411) expressed in E. Coli. | |
| 100 μg | |
| Primary | |
| Human | |
| Antibody | |
| IgG1 |
| ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry | |
| 2G5 | |
| Unconjugated | |
| DCX | |
| DBCN; Dbct; DC; Dcn; DCX; doublecortex; doublecortin; doublin; lissencephalin-X; lissencephaly, X-linked (doublecortin); LISX; Lis-X; LIS-XD; Neuronal migration protein doublecortin; OTTHUMP00000023860; OTTHUMP00000216316; SCLH; XLIS | |
| Mouse | |
| Protein G | |
| RUO | |
| 1641 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |