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Invitrogen™ DLAT Recombinant Rabbit Monoclonal Antibody (23GB1010)
Rabbit Recombinant Monoclonal Antibody
$656.94 - $1,779.35
Specifications
| Antigen | DLAT |
|---|---|
| Clone | 23GB1010 |
| Concentration | 0.2 mg/mL |
| Content And Storage | -20°C |
| Applications | Flow Cytometry, Western Blot, Immunocytochemistry |
Description
DLAT Recombinant Monoclonal Antibody for Western Blot, ICC/IF, Flow
DLAT encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC eventually leads to cirrhosis and liver failure.Specifications
| DLAT | |
| 0.2 mg/mL | |
| Flow Cytometry, Western Blot, Immunocytochemistry | |
| Unconjugated | |
| Rabbit | |
| RUO | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.4 | |
| P08461, P10515, Q8BMF4 | |
| 1737, 235339, 81654 | |
| A synthetic peptide of human Pyruvate Dehydrogenase E2 (594-608AA). | |
| Antibody |
| 23GB1010 | |
| -20°C | |
| Recombinant Monoclonal | |
| Liquid | |
| IgG | |
| Human, Mouse, Rat | |
| DLAT | |
| 6332404G05Rik; 70 kDa mitochondrial autoantigen of primary biliary cirrhosis; anti DLAT; Dihydrolipoamide; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; dihydrolipoamide S-acetyltransferase; dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex); dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex mitochondrial; dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial; DLAT; DLTA; E2; E2 component of pyruvate dehydrogenase complex; EC 2.3.1.12; M2 antigen complex 70 kDa subunit; ODP2; PBC; PDC PDC-E2; PDCE2; PDC-E2; pyruvate dehydrogenase complex component E2 | |
| DLAT | |
| Primary | |
| Affinity chromatography |