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DL-Thioctic acid, 98%

Catalog No. p-7044125
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Quantity:
25 g
5 g
Catalog No. Quantity
AAL0471106 5 g
AAL0471114 25 g
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Catalog No. AAL0471106

Supplier: Thermo Scientific Chemicals L0471106

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Description

DL-Thioctic acid, CAS # 1077-28-7, is an antioxidant and coenzyme important for the activity of enzymes. | CAS: 1077-28-7 | C8H14O2S2 | 206.32 g/mol

DL-Thioctic acid plays an essential role in aerobic metabolism. Further, it acts as a free radical scavenger.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• DL-Thioctic acid derives from octanoic acid, and it has been described as an antioxidant coenzyme important for the activity of enzyme complexes including pyruvate dehydrogenase and glycine decarboxylase

Application

• DL-Thioctic acid has been used in studies to increase insulin sensitivity and stimulate glucose uptake into adipose and muscle cells in vitro

• DL-Thioctic acid has an essential role in aerobic metabolism

• It has been used as free radical scavenger compound

• It can also assist in repairing oxidative damage via the increase of endogenous antioxidants, including vitamins C, vitamin E, and glutathione

• It can induce apoptosis through caspase-independent and caspase-dependent pathways, a process mediated by intracellular Ca2+

• DL-Thioctic acid has the ability to impact various cellular biological pathways since it can increase glutathione synthesis and modulate transcription factor activity, mainly nuclear factor kappa B (NF-κB)

• It can decrease the phagocytosis of myelin by macrophages

Chemical Identifiers

CAS 1077-28-7
Molecular Formula C8H14O2S2
Molecular Weight (g/mol) 206.32
MDL Number MFCD00005474
InChI Key AGBQKNBQESQNJD-UHFFFAOYNA-N
Synonym dl-thioctic acid, thioctic acid, alpha-lipoic acid, 5-1,2-dithiolan-3-yl pentanoic acid, dl-alpha-lipoic acid, 1,2-dithiolane-3-pentanoic acid, 6,8-thioctic acid, thioctacid, 6-thioctic acid, alpha lipoic acid
PubChem CID 864
ChEBI CHEBI:16494
IUPAC Name 5-(1,2-dithiolan-3-yl)pentanoic acid
SMILES OC(=O)CCCCC1CCSS1

Specifications

Melting Point 59°C to 63°C
Boiling Point 160°C to 165°C
Quantity 5 g
Beilstein 81853
Merck Index 14,9326
Solubility Information Soluble in methanol,ethanol,diethyl ether and chloroform. Insoluble in water.
Formula Weight 206.33
Percent Purity 98%
Chemical Name or Material DL-Thioctic acid

Safety and Handling

Hazard Category H302-H315-H319-H335
Hazard Statement GHS H Statement
H302-H315-H319-H335
Harmful if swallowed.
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.
Precautionary Statement P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P362-P501c
EINECSNumber 214-071-2
RTECSNumber JP1192000
TSCA No
Recommended Storage Keep cold

RUO – Research Use Only