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Cyclopamine, 99%
CAS: 4449-51-8 | C27H41NO2 | 411.63 g/mol
$568.42 - $963.86
Chemical Identifiers
| CAS | 4449-51-8 |
|---|---|
| Molecular Formula | C27H41NO2 |
| Molecular Weight (g/mol) | 411.63 |
| MDL Number | MFCD01735266 |
| InChI Key | QASFUMOKHFSJGL-LAFRSMQTSA-N |
| Synonym | cyclopamine, 3b,23b-17,23-epoxy-11-deoxoveratraman-3-ol |
| PubChem CID | 122130428 |
| SMILES | C[C@@H]1[C@@H]2NC[C@@H](C)C[C@H]2O[C@]11CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC2=C1C |
| Catalog Number | Mfr. No. | Quantity | Price | Quantity | |||||
|---|---|---|---|---|---|---|---|---|---|
| Catalog Number | Mfr. No. | Quantity | Price | Quantity | |||||
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AAJ61528MB
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Thermo Scientific Chemicals
J61528MB |
25 mg |
Each for $568.42
|
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AAJ61528MF
|
Thermo Scientific Chemicals
J61528MF |
50 mg |
Each for $963.86
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Description
Cyclopamine, is used as a hedgehog [Hh] signaling pathway and Smo inhibitor. It depletes stem-like cancer cells in glioblastoma and blocks tumor engraftment. Can also be used to induce differentiation of human embryonic stem cells (hESCs) into hormone-expressing endocrine cells.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
ApplicationsCyclopamine, is used as a hedgehog [Hh] signaling pathway and Smo inhibitor. It depletes stem-like cancer cells in glioblastoma and blocks tumor engraftment. Can also be used to induce differentiation of human embryonic stem cells (hESCs) into hormone-expressing endocrine cells.
Solubility
Soluble in ethanol (5 mg/ml warm), DMSO (4 mg/ml), DMF (10 mg/ml), methylene chloride, chloroform, methanol (7 mg/ml), and benzene.
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8°C. Keep away from strong oxidizing agents.
Chemical Identifiers
| 4449-51-8 | |
| 411.63 | |
| QASFUMOKHFSJGL-LAFRSMQTSA-N | |
| 122130428 |
| C27H41NO2 | |
| MFCD01735266 | |
| cyclopamine, 3b,23b-17,23-epoxy-11-deoxoveratraman-3-ol | |
| C[C@@H]1[C@@H]2NC[C@@H](C)C[C@H]2O[C@]11CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC2=C1C |
Specifications
| 4449-51-8 | |
| White | |
| MFCD01735266 | |
| cyclopamine, 3b,23b-17,23-epoxy-11-deoxoveratraman-3-ol | |
| QASFUMOKHFSJGL-LAFRSMQTSA-N | |
| (3S,3'R,3'aS,6'S,6aS,9S)-3',6',10,11b-tetramethylspiro[2,3,4,6,6a,6b,7,8,11,11a-decahydro-1H-benzo[a]fluorene-9,2'-3a,4,5,6,7,7a-hexahydro-3H-furo[3,2-b]pyridine]-3-ol | |
| 122130428 | |
| ≥99% | |
| Cyclopamine |
| 234°C to 237°C | |
| C27H41NO2 | |
| 25 mg | |
| Soluble in ethanol (5mg/ml warm),DMSO (4mg/ml),DMF (10mg/ml),methylene chloride,chloroform,methanol (7mg/ml),and benzene. | |
| C[C@@H]1[C@@H]2NC[C@@H](C)C[C@H]2O[C@]11CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC2=C1C | |
| 411.63 | |
| 411.62 | |
| Powder |
Safety and Handling
GHS H Statement
H341-H361
Suspected of causing genetic defects.
Suspected of damaging fertility or the unborn child.
P201-P202-P281-P308+P313-P501c
H341-H361
RTECSNumber : GY0750000
TSCA : No
Recommended Storage : Store at -20°C
RUO – Research Use Only