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Invitrogen™ CSK Monoclonal Antibody (C.678.4)
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Catalog No. pima514915
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Quantity:
100 μL
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Catalog No. Quantity
PIMA514915 100 μL
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Catalog No. PIMA514915 Supplier Invitrogen™ Supplier No. MA514915
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Description

Rabbit Monoclonal Antibody

It is not recommended to aliquot this antibody. This antibody is not cross-reactive with other proteins.

CSK is a tyrosine kinase that has been shown to downregulate the activity of SRC oncoprotein through phosphorylation of its carboxy terminus. Since cell transformation by SRC is caused by various mechanisms that interfere with this phosphorylation, the CSK gene might function as an antioncogene. CSK plays an important role in the regulation of cell growth, differentiation, migration, and immune responses. CSK phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases including LCK, SRC, HCK, FYN, LYN, CSK, and YES1. CSK is expressed ubiquitously as a protein of approximately 50 KDa in cytosol, but a fraction distributes to lipid rafts due to interaction with the lipid raft-associated protein PAG (Csk-binding protein).

Specifications

Antigen CSK
Applications Western Blot
Classification Monoclonal
Clone C.678.4
Concentration 29 μg/mL
Conjugate Unconjugated
Formulation 0.01M HEPES with 100μg/mL BSA, 0.15M NaCl, 50% glycerol and <0.02% sodium azide; pH 7.5
Gene CSK
Gene Accession No. P32577, P41240, P41241
Gene Alias AW212630; CSK; CSK, non-receptor tyrosine kinase; C-SRC kinase; c-src tyrosine kinase; C-terminal Src kinase; MGC117393; p50CSK; protein-tyrosine kinase (CSK); protein-tyrosine kinase CYL; Protein-tyrosine kinase MPK-2; Tyrosine-protein kinase CSK
Gene Symbols CSK
Host Species Rabbit
Immunogen Synthetic peptide corresponding to residues surrounding amino acid residue Val399 of human Csk.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100154110, 12988, 1445, 315707
Target Species Human, Mouse, Rat, Monkey, Pig
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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