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Invitrogen™ COP1 Polyclonal Antibody
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Catalog No. PIPA5141993
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100 μg
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Catalog No. Quantity
PIPA5141993 100 μg
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Catalog No. PIPA5141993 Supplier Invitrogen™ Supplier No. PA5141993
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Description

Goat Polyclonal Antibody

Additional Information: This antibody is expected to recognize isoform 2 (NP_443121.1) only. In addition there may be cross-reaction with INCA (GeneID 440068; NP_001007233.1). This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:4,000.

Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2. [UniProt].

Specifications

Antigen COP1
Applications Flow Cytometry, Immunocytochemistry
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Gene CARD16
Gene Accession No. Q5EG05
Gene Alias CARD only domain-containing protein 1; CARD only protein; CARD16; CARD-only protein 1; caspase recruitment domain family member 16; caspase recruitment domain family, member 16; caspase recruitment domain-containing protein 16; Caspase recruitment domain-only protein 1; caspase-1 dominant-negative inhibitor pseudo-ICE; caspase-1 inhibitor COP; Constitutive photomorphogenesis protein 1 homolog; constitutive photomorphogenic protein 1; COP; COP1; E3 ubiquitin-protein ligase COP1; E3 ubiquitin-protein ligase RFWD2; hCOP1; Pseudo interleukin-1 beta converting enzyme; pseudo interleukin-1beta converting enzyme; PSEUDO-ICE; pseudo-IL1B-converting enzyme; putative ubiquitin ligase COP1; RFWD2; ring finger and WD repeat domain 2; ring finger and WD repeat domain 2, E3 ubiquitin protein ligase; RING finger and WD repeat domain protein 2; RING finger protein 200; RING-type E3 ubiquitin transferase RFWD2; RNF200
Gene Symbols CARD16
Host Species Goat
Immunogen Peptide with sequence C-ETLGLSAGPIPGN.
Purification Method Ammonium sulfate precipitation
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 114769
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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