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Invitrogen™ CNOT7 Polyclonal Antibody
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Catalog No. pipa5101270
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PIPA5101270 100 μL
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Catalog No. PIPA5101270 Supplier Invitrogen™ Supplier No. PA5101270
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total CNOT7.

CNOT7 (CCR4-NOT transcription complex subunit 7) has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. CNOT7 is a catalytic component of the CCR4-NOT complex, which is one of the major cellular mRNA deadenylases, and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation, and general transcription regulation. During miRNA-mediated repression, the complex seems to act as a transcriptional repressor during translational initiation, as well. Additional complex functions may be a consequence of its influence on mRNA expression. CNOT7 associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.

Specifications

Antigen CNOT7
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene CNOT7
Gene Accession No. Q60809, Q9UIV1
Gene Alias AU022737; BTG1-binding factor 1; CAF1; CAF-1; Caf1a; carbon catabolite repressor protein (CCR4)-associative factor 1; catabolite repressor protein (CCR4)-associative factor 1; CCR4-associated factor 1; CCR4-NOT transcription complex subunit 7; CCR4-NOT transcription complex subunit-like protein; CCR4-NOT transcription complex, subunit 7; CNOT7; fd59c07; fj07d05; hCAF-1; hypothetical protein LOC508055; Pop2; POP2 homolog; wu:fd59c07; wu:fj07d05; zgc:153168
Gene Symbols CNOT7
Host Species Rabbit
Immunogen A synthesized peptide derived from human CNOT7(Accession Q9UIV1), corresponding to amino acid residues E243-S285.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18983, 29883
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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