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Invitrogen™ CNOT4 Monoclonal Antibody (OTI3D11)
Mouse Monoclonal Antibody
Supplier: Invitrogen™ MA525914
Description
CNOT4 Monoclonal Antibody for Western Blot, Flow
CNOT4 is a 575 amino acid protein with E3 ubiquitin ligase activity, mainly involved in protein modification and protein ubiquitination. It contains a ring type zinc finger domain of the C4C4 type, an RNA recognition motif and a bipartite nuclear localization signal.Studies show that CNOT4 is a component of the CCR4-NOT (CAF1) core complex that functions as general transcription regulation complex and has both a positive as well as a negative effect on the transcription of multiple functionally unrelated genes, thus controls gene expression. CNOT4 interacts with CNOT1 via C-terminus and with E2 ubiquitin ligases via C4C4 RING domain. Reports suggest that CNOT4 gets phosphorylated in response to DNA damage on consensus sites recognized by ATM and ATR.Specifications
| CNOT4 | |
| Monoclonal | |
| 0.81 mg/mL | |
| PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3 | |
| O95628 | |
| CNOT4 | |
| Human recombinant protein fragment corresponding to ammino acids 190-455 of CNOT4 produced in E.coli. | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG1 |
| Flow Cytometry, Western Blot | |
| OTI3D11 | |
| Unconjugated | |
| CNOT4 | |
| CCR4-associated factor 4; CCR4-NOT transcription complex subunit 4; CCR4-NOT transcription complex subunit 4 L homeolog; CCR4-NOT transcription complex subunit 4 S homeolog; CCR4-NOT transcription complex subunit 4 S homeolog; CCR4-NOT transcription complex, subunit 4; CCR4-NOT transcription complex, subunit 4 isoform a; CLONE243; cnot4; cnot4.S; E3 ubiquitin-protein ligase CNOT4; hypothetical protein; negative regulator of transcription 4; Not4; NOT4 (negative regulator of transcription 4, yeast) homolog; Not4h; Not4hp; Potential transcriptional repressor NOT4Hp; RING-type E3 ubiquitin transferase CNOT4; transcriptional repressor NOT4Hp; XELAEV_18019807mg | |
| Mouse | |
| Affinity Chromatography | |
| RUO | |
| 4850 | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| Liquid |