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  6. Invitrogen™ CHCHD6 Monoclonal Antibody (K56003_20B7), Invitrogen™

Invitrogen™ CHCHD6 Monoclonal Antibody (K56003_20B7), Invitrogen™

Catalog No. MA555691
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200 μL
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MA555691 50 μL
MA556071 200 μL
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Catalog No. MA555691 Supplier Invitrogen™ Supplier No. MA555691
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Description

Mouse Monoclonal Antibody

Sequence of this protein is as follows: RVSFGVDEEE RVRVLQGVRL SENVVNRMKE PSSPPPAPTS STFGLQDGNL RAPHKESTLP RSGSSGGQQP SGMKEGVKRY EQEHAAIQDK LFQVAKRERE AATKHSKASL PTGEGSISHE EQKSVRLARE LESREAELRR RDTFYKEQLE RIERKNAEMY KLSSEQFHEA ASKMESTIKP

CHCHD6 is a member of a family of proteins containing a conserved (coiled coil 1)-(helix 1)-(coiled coil 2)-(helix 2) domain and has been observed in a complex with the mitochondrial proteins mitofilin, SAM50, metaxins 1 and 2, and CHCHD3. CHCHD6 knockdown causes severe defects in mitochondrial cristae morphology as well as reductions in cell growth, ATP production and oxygen consumption. This decrease of CHCHD6 also led to a reduction in mitofilin protein levels, while a knockdown of mitofilin resulted in a reduced level of CHCHD6, suggesting coordinate regulation between these two proteins. CHCHD6 knockdown in human cancer cells enhances their sensitivity to genotoxic anticancer drugs, suggesting that CHCHD6 may be a potential therapeutic anti-tumor target.

Specifications

Antigen CHCHD6
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone K56003_20B7
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol, 0.5% BSA and 0.09% sodium azide
Gene CHCHD6
Gene Accession No. Q91VN4, Q9BRQ6
Gene Alias 0710001P09Rik; 1700021B03Rik; CHCHD6; CHCM1; coiled coil helix cristae morphology 1; coiled coil helix cristae morphology protein 1; coiled-coil-helix cristae morphology 1; coiled-coil-helix cristae morphology protein 1; coiled-coil-helix-coiled-coil-helix domain containing 6; Coiled-coil-helix-coiled-coil-helix domain-containing protein 6; coiled-coil-helix-coiled-coil-helix domain-containing protein 6, mitochondrial; Mic25; MICOS complex subunit MIC25; PPP1R23; protein phosphatase 1, regulatory subunit 23
Gene Symbols CHCHD6
Host Species Mouse
Immunogen Recombinant human CHCHD6 (immunogen range is 11-190).
Purification Method Protein A
Quantity 50 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 66098, 84303
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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