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Invitrogen™ CDK9 Recombinant Rabbit Monoclonal Antibody (1C4E3)
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Catalog No. PIMA542642
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Catalog No. Quantity
PIMA542642 100 μL
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Catalog No. PIMA542642 Supplier Invitrogen™ Supplier No. MA542642
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Description

Rabbit Recombinant Monoclonal Antibody

Positive test controls include: HeLa, 293T, MCF7, Mouse brain, Rat testis, Rat brain. The target is usually found in the following locations: Cytoplasm, Nucleus, PML body.

CDK9 is a serine/threonine kinase which when complexed with CyclinT1 forms an active holoenzyme complex. This complex plays a key role in regulating the eukaryotic cell cycle. CDK9 is coexpressed and copurified with CyclinT1. CDK9 regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors. CDK9 promotes RNA synthesis in genetic programs for cell growth, differentiation, and viral pathogenesis. The CDK9/cyclin-K complex also has kinase activity towards CTD of RNAPII and can substitute for CDK9/cyclin-T P-TEFb in vitro. Chronic activation of CDK9 causes cardiac myocyte enlargement leading to cardiac hypertrophy and confers a predisposition to heart failure.

Specifications

Antigen CDK9
Applications ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry, Immunoprecipitation, Western Blot
Classification Recombinant Monoclonal
Clone 1C4E3
Concentration 0.25 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene CDK9
Gene Accession No. P50750, Q641Z4, Q99J95
Gene Alias C-2k; CDC2L4; CDC2-related kinase; Cdk9; Cell division cycle 2-like protein kinase 4; Cell division protein kinase 9; CTK1; cyclin dependent kinase 9; cyclin-dependent kinase 9; cyclin-dependent kinase 9 (CDC2-related kinase); PITALRE; RP11-228B15.5; serine/threonine protein kinase PITALRE; Serine/threonine-protein kinase PITALRE; TAK; Tat-associated kinase complex catalytic subunit
Gene Symbols CDK9
Host Species Rabbit
Immunogen Synthetic peptide.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1025, 107951, 362110
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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