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Invitrogen™ CD31 Polyclonal Antibody
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Catalog No. PIPA516301
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500 μL
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PIPA516301 500 μL
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Catalog No. PIPA516301 Supplier Invitrogen™ Supplier No. PA516301

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Description

Rabbit Polyclonal Antibody

Recommended positive controls: IHC (P): Mouse skin and xenograft tissue, human tonsil tissue WB: Jurkat whole cell lysate, human vascular endothelial cell lysate IHC (F): Human fetal heart tissue.

CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases. CD31 is expressed ubiquitously within the vascular compartment and is located mainly at junctions between adjacent cells. N-terminal Ig-like domain of CD31 is responsible for its homophilic binding, which plays an important role in cell-cell interactions. CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulation of immunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. It is one of key regulatory molecules in vascular system.

Specifications

Antigen CD31
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA and 0.1% sodium azide; pH 7.2
Gene Pecam1
Gene Accession No. P16284
Gene Alias C85791; CD31; CD31 antigen; CD31, PECAM-1; CD31/EndoCAM; endoCAM; GPIIA'; I79_008304; PECA1; Pecam; PECAM1; Pecam-1; platelet and endothelial cell adhesion molecule 1; platelet endothelial cell adhesion molecule; platelet endothelial cell adhesion molecule-1; platelet/endothelial cell adhesion molecule (CD31 antigen); platelet/endothelial cell adhesion molecule 1; type I transmembrane endothelial adhesion molecule
Gene Symbols Pecam1
Host Species Rabbit
Immunogen Synthetic peptide corresponding to mouse CD31, aa 700 to the C-terminus.
Purification Method Antigen affinity chromatography
Quantity 500 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5175
Target Species Human
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG
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