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Invitrogen™ CD28 Chimeric Recombinant Rabbit Monoclonal Antibody (15E8)
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Catalog No. MA551761
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200 μg
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Catalog No. Quantity
MA551761 200 μg
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Catalog No. MA551761 Supplier Invitrogen™ Supplier No. MA551761
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Description

Rabbit Recombinant Monoclonal Antibody

This antibody binds human CD28, which is found on a sub-population of T cells and activated B cells. The antibody does not react with B cells, granulocytes or monocytes. CD28 is involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.

CD28 antigen is a 44 kDa disulfide linked homodimeric T cell specific surface glycoprotein. CD28 is a cell adhesion molecule of the immunoglobulin superfamily which is constitutively expressed on most peripheral blood T lymphocytes. Moreover, CD28 is the critical T cell costimulatory receptor that provides the cell the important second activation signal by binding CD80 and CD86 which are expressed by antigen presenting cells. In addition to its co-stimulation role, CD28 functions by preventing T cells from entering an anergic-hyporesponsive state or from undergoing premature apoptotic cell death. In murine peripheral lymphoid organs and in the blood, all CD4+ and CD8+ T cells express CD28. In the thymus, CD28 expression is highest on immature CD3-, CD8+ and CD4+8+ cells, and on CD4-8- cells that express alpha/beta and gamma/delta TCR. The level of CD28 on mature CD4+ and CD8+ alpha/beta TCR+ thymocytes is two- to fourfold lower than on the immature cells. Diseases associated with CD28 dysfunction include mycosis fungiodes and Sezary's Disease.

Specifications

Antigen CD28 Chimeric
Applications ELISA, Functional Assay
Classification Recombinant Monoclonal
Clone 15E8
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% ProClin 300
Gene Cd28
Gene Accession No. P10747
Gene Alias antigen CD28; CD28; CD28 antigen; CD28 antigen (Tp44); CD28 isoform; CD28 isoform 2; Cd28 molecule; CD28 precursor protein; CD28 protein; CD28 protein precursor; CD28RNA; cell surface protein; CHT28; contains partial extracellular domain; costimulatory molecule B7 receptor CD28; EGK_04709; MGC138290; sCD28; soluble CD28; T44; T-cell costimulatory molecule CD28; T-cell costimulatory molecule Tp44; T-cell-specific surface glycoprotein CD28; T-cell-specific surface glycoprotein CD28 homolog; TP44
Gene Symbols Cd28
Host Species Rabbit
Immunogen The original mouse antibody was generated by immunizing mice with human T lymphocytes.
Purification Method Protein A
Quantity 200 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 940
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG κ
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