Invitrogen™ CCDC14 Polyclonal Antibody

Description

Immunogen sequence: IIYQALCEHV QTQMSLMNDL TSKNIPNGIP AVPCHAPSHS ESQATPHSSY GLCTSTPVWS LQRPPCPPKV HSEVQTDGNS QFASQG Highest antigen sequence identity to the following orthologs: Mouse - 67%, Rat - 64%.

CCDC14 (Coiled-Coil Domain-Containing 14) is a gene that encodes a protein involved in ciliary function and cellular division processes. This protein contains coiled-coil domains that facilitate protein-protein interactions crucial for the assembly and stabilization of microtubule structures within the cell. Research indicates that CCDC14 is essential for proper ciliogenesis, the process by which cells form cilia, which are vital for cell motility, fluid movement, and signal transduction. Additionally, studies have revealed its significant role in the regulation of cell cycle progression and cytokinesis. CCDC14 is required for the accurate segregation of chromosomes during cell division, ensuring genomic stability. Mutations or dysregulation of CCDC14 can lead to ciliopathies and other cellular dysfunctions, highlighting its critical role in maintaining normal cellular activities and its potential implications in various diseases.