Invitrogen™ Cathepsin A (Cleaved Arg326) Polyclonal Antibody

Description

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Cathepsin A, also known as protective protein/cathepsin A (PPCA), is a lysosomal serine protease encoded by the CTSA gene. It is a member of the alpha/beta hydrolase fold family, sharing structural homology with yeast carboxypeptidase Y. Cathepsin A functions predominantly in protein degradation within acidic endo/lysosomal compartments. It is involved in numerous physiological processes including intracellular protein degradation, energy metabolism, immune responses, and peptide synthesis. Particularly, the cleavage at Arg326 is significant as it pertains to its activation or functional modifications. Cathepsin A operates in conjunction with other enzymes such as neuraminidase and beta-galactosidase in a multi-enzyme complex, which is crucial for the lysosomal degradation pathways. Dysfunctions or mutations in the CTSA gene are associated with galactosialidosis, a lysosomal storage disorder characterized by a deficiency in these enzymatic activities.