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Castanospermine, 99%

Catalog No. p-7042021
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Quantity:
100 mg
500 mg
Catalog No. Quantity
AAJ61071MC 100 mg
AAJ61071ME 500 mg
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Catalog No. AAJ61071MC

Supplier: Thermo Scientific Chemicals J61071MC

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Description

Potent alpha and beta-glucosidase inhibitor | CAS: 79831-76-8 | C8H15NO4 | 189.211 g/mol

Castanospermine, is used as a glycosidase inhibitor and antiinflammatory agent.castanospermine is used to inhibit syncytium formation between HIV-infected and CD4-expressing cells and may also interfere with infectivity. It has also been demonstrated that this agent inhibits inflammation at the level of leukocyte extravasation in rat models of experimental adjuvant-induced arthritis and autoimmune encephalomyelitis. Castanospermine is an inhibitor of Glucosidase I, Maltase-glucoamylase, and MANBA. Potent inhibitor of α- and β-glucosidases, especially glucosidase l (required for glucoprotein processing by transfer of mannose and glucose from asparagine-linked lipids). Inhibits HIV syncytium formation and replication.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Castanospermine, is used as a glycosidase inhibitor and antiinflammatory agent.castanospermine is used to inhibit syncytium formation between HIV-infected and CD4-expressing cells and may also interfere with infectivity. It has also been demonstrated that this agent inhibits inflammation at the level of leukocyte extravasation in rat models of experimental adjuvant-induced arthritis and autoimmune encephalomyelitis. Castanospermine is an inhibitor of Glucosidase I, Maltase-glucoamylase, and MANBA. Potent inhibitor of α- and β-glucosidases, especially glucosidase l (required for glucoprotein processing by transfer of mannose and glucose from asparagine-linked lipids). Inhibits HIV syncytium formation and replication.

Solubility
Soluble in water

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8°C. Keep away from strong oxidizing agents.

Chemical Identifiers

CAS 79831-76-8
Molecular Formula C8H15NO4
Molecular Weight (g/mol) 189.211
MDL Number MFCD00017555
InChI Key JDVVGAQPNNXQDW-TVNFTVLESA-N
Synonym castanospermine, castinospermine, 1,6,7,8-tetrahydroxyoctahydroindolizine, 1s,6s,7r,8r,8ar-1,6,7,8-tetrahydroxyindolizidine, 6-epicastanospermine, unii-q0i3184xm7, 6,7-diepicastanospermine, castanospermine, castanospermum australe, 1s,6s,7r,8ar-tetrahydroxyoctahydroindolizine, 1s,6s,7r,8r,8ar-octahydroindolizine-1,6,7,8-tetrol
PubChem CID 54445
ChEBI CHEBI:27860
IUPAC Name (1S,6S,7R,8R,8aR)-1,2,3,5,6,7,8,8a-octahydroindolizine-1,6,7,8-tetrol
SMILES C1CN2CC(C(C(C2C1O)O)O)O

Specifications

Melting Point 213°C to 217°C
Color White
Quantity 100 mg
Beilstein 3588654
Merck Index 14,1896
Solubility Information Soluble in water
Formula Weight 189.21
Percent Purity 99%
Physical Form Solid
Chemical Name or Material Castanospermine

Safety and Handling

Hazard Category H302+H312+H332
Hazard Statement GHS H Statement
H302-H312-H332
Harmful if swallowed.
Harmful in contact with skin.
Harmful if inhaled.
Precautionary Statement P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P312-P330-P363-P501c
TSCA No
Recommended Storage Keep cold

RUO – Research Use Only