Invitrogen™ Caspase 7 p11 Polyclonal Antibody

Description

Recommended positive controls: 293T, A431, HeLa, HepG2, Jurakt, Jurakt (10 μM etoposide treatment for 24 hr). Predicted reactivity: Mouse (91%), Rat (91%), Zebrafish (83%), Xenopus laevis (82%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of this caspase is cleaved by caspase 3 and 10. It is activated upon cell death stimuli and induces apoptosis. Alternative splicing results in four transcript variants, encoding three distinct isoforms.