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Invitrogen™ Caspase 12 Monoclonal Antibody (14F7)
Rat Monoclonal Antibody
Supplier: Invitrogen™ MA124704
Description
Recommended positive controls: NRK.
Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the mains, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including -gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues.Specifications
| Caspase 12 | |
| Monoclonal | |
| 2.2 mg/mL | |
| PBS with 15mM sodium azide; pH 7.4 | |
| O08736, Q920D5 | |
| CASP12 | |
| Recombinant mouse caspase 12 (residues 95-318). | |
| 50 μL | |
| Primary | |
| Mouse, Rat | |
| Antibody | |
| IgG2a |
| Immunohistochemistry, Immunoprecipitation, Western Blot, Immunocytochemistry | |
| 14F7 | |
| Unconjugated | |
| CASP12 | |
| CASP12; CASP-12; CASP12P1; caspase 12; caspase 12 (gene/pseudogene); caspase 12 pseudogene 1; caspase-12; Inactive caspase-12; OTTMUSP00000045799; OTTMUSP00000045802; OTTMUSP00000045803; UNQ9415; UNQ9415/PRO34398 | |
| Rat | |
| Purified | |
| RUO | |
| 12364, 156117 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |