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Invitrogen™ Caspase 1 p20 (Cleaved Asp296) Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA599390
Description
Antibody detects endogenous levels of fragment of activated Caspase-1 resulting from cleavage adjacent to Asp296.
Caspase-1 (CASP1) is a thiol protease that cleaves IL-1 beta between Asp and Ala. This cleavage causes the release of the mature cytokine which is involved in a variety of inflammatory processes. CASP1 is important for defense against pathogen. It cleaves and activates sterol regulatory element binding proteins (SREBPs). CASP1 also promotes apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, CASP1 controls antiviral immunity through the cleavage of CGAS and renders it inactive.Chemical Identifiers
| Caspase 1 p20 (Cleaved Asp296) | |
| -20°C | |
| Polyclonal | |
| Liquid | |
| IgG | |
| Human, Mouse, Rat | |
| Casp1 | |
| CASP1; CASP-1; CASP1 nirs variant 1; caspase 1; caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase); caspase-1; Caspase-1 subunit p10; Caspase-1 subunit p20; Ice; IL-1 beta-converting enzyme; IL-1B converting enzyme; IL1BC; IL-1BC; IL1BCE; IL1B-convertase; interleukin 1 beta-converting enzyme; interleukin 1, beta, convertase; interleukin 1-B converting enzyme; Interleukin 1beta converting enzyme; interleukin-1 beta convertase; Interleukin-1 beta-converting enzyme; p45 | |
| Casp1 | |
| Primary | |
| Affinity chromatography |
| 1 mg/mL | |
| Immunohistochemistry (Paraffin), Western Blot | |
| Unconjugated | |
| Rabbit | |
| RUO | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.4 | |
| P29452, P29466, P43527 | |
| 12362, 25166, 834 | |
| A synthesized peptide derived from human CASP1(Accession P29466), corresponding to amino acid residues I280-V299. | |
| Antibody |
Specifications
| Caspase 1 p20 (Cleaved Asp296) | |
| Polyclonal | |
| Unconjugated | |
| Casp1 | |
| CASP1; CASP-1; CASP1 nirs variant 1; caspase 1; caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase); caspase-1; Caspase-1 subunit p10; Caspase-1 subunit p20; Ice; IL-1 beta-converting enzyme; IL-1B converting enzyme; IL1BC; IL-1BC; IL1BCE; IL1B-convertase; interleukin 1 beta-converting enzyme; interleukin 1, beta, convertase; interleukin 1-B converting enzyme; Interleukin 1beta converting enzyme; interleukin-1 beta convertase; Interleukin-1 beta-converting enzyme; p45 | |
| Rabbit | |
| Affinity chromatography | |
| RUO | |
| 12362, 25166, 834 | |
| -20°C | |
| Liquid |
| Immunohistochemistry (Paraffin), Western Blot | |
| 1 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.4 | |
| P29452, P29466, P43527 | |
| Casp1 | |
| A synthesized peptide derived from human CASP1(Accession P29466), corresponding to amino acid residues I280-V299. | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |