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PeproTech Cardiotrophin 1 Polyclonal Antibody, PeproTech®, Invitrogen™

Catalog No. 500P1011MG
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100 μg
50 μg
1 mg
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Catalog No. Quantity
500P1011MG 1 mg
500P10150UG 50 μg
500P101100 100 μg
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Catalog No. 500P1011MG Supplier PeproTech Supplier No. 500P1011MG
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Description

Rabbit Polyclonal Antibody

AA Sequence of recombinant protein: SRREGSLEDP QTDSSVSLLP HLEAKIRQTH SLAHLLTKYA EQLLQEYVQL QGDPFGLPSF SPPRLPVAGL SAPAPSHAGL PVHERLRLDA AALAALPPLL DAVCRRQAEL NPRAPRLLRR LEDAARQARA LGAAVEALLA ALGAANRGPR AEPPAATASA ASATGVFPAK VLGLRVCGLY REWLSRTEGD LGQLLPGGSA. Preparation: Produced from sera of rabbits immunized with highly pure Recombinant Human Cardiotrophin-1. Anti-Human Cardiotrophin-1-specific antibody was purified by affinity chromatography employing an immobilized Human Cardiotrophin-1 matrix. Sandwich ELISA: To detect Human Cardiotrophin-1 by sandwich ELISA (using 100 μL/well antibody solution) a concentration of 0.5-2.0 μg/mL of this antibody is required. This antigen affinity purified antibody, in conjunction with PeproTech Biotinylated Anti-Human Cardiotrophin-1 (500-P101Bt) as a detection antibody, allows the detection of at least 0.2-0.4 ng/well of Recombinant Human Cardiotrophin-1. Western Blot: To detect Human Cardiotrophin-1 by Western Blot analysis this antibody can be used at a concentration of 0.1-0.2 μg/mL. Used in conjunction with compatible secondary reagents the detection limit for Recombinant Human Cardiotrophin-1 is 1.5-3.0 ng/lane, under reducing or non-reducing conditions.

Cardiotrophin-1 (CT-1) is a member of the IL-6 family of cytokines, which signal through gp130 receptor complexes. gp130 complexes with several different receptor subunits to transmit signals from Cardiotrophin-1, IL-6, LIF, OSM, CNTF and IL-11. Cardiotrophin-1 binds to and activates the leukemia inhibitory factor (LIF) receptor/gp130 receptor complex and has been shown to induce hypertrophy in cardiac myocytes in vitro. Cardiotrophin-1, a secreted protein expressed at high levels in myocardium during cardiogenesis, has been shown to promote proliferation and survival of embryonic cardiomyocytes, suggesting a role for Cardiotrophin-1 in the activation of gp130 during cardiac development.

Specifications

Antigen Cardiotrophin 1
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.1-1.0 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene CTF1
Gene Accession No. Q16619
Gene Alias cardiophin 1; Cardiotrophin; cardiotrophin 1; Cardiotrophin1; cardiotrophin-1; CT 1; CT1; CT-1; CT-1CT1; CTF 1; Ctf1; IL-6 cytokine family
Gene Symbols CTF1
Host Species Rabbit
Immunogen E.coli-derived Recombinant Human Cardiotrophin-1.
Purification Method Antigen affinity chromatography
Quantity 1 mg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1489
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Lyophilized
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