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Candesartan, 98%
Angiotensin II receptor antagonist | CAS: 139481-59-7 | C24H20N6O3 | 440.463 g/mol
Supplier: Thermo Scientific Chemicals J6281803
Description
Candesartan is a selective AT1 (angiotensin II receptor 1) antagonist. Antagonism of angiotensin receptors inhibits vasoconstriction and the production of aldosterone, leading to a decrease in water and sodium concentration in blood plasma. Exhibits antihypertensive effects in animal models. Used in treatment of congestive heart failure, as antihypertensive. Candesartan does not affect cell viability or proliferation but increases the expression of VEGF and interleukin-8 in the cultured medium of KU-19-19 cells. Candesartan (0.1 nM) could reduce the maximal contractile response to angiostensin II by approximately 50%.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
SolubilitySoluble in ethyl acetate, methanol, water (<1mg/mL at 25°C), DMSO (88 mg/ml at 25°C), and ethanol (1 mg/ml at 25°C).
Notes
Store away from oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.
Specifications
| Candesartan | |
| 183°C to 185°C | |
| C24H20N6O3 | |
| 1 g | |
| candesartan, blopress, ratacand, 1-2'-1h-tetrazol-5-yl-1,1'-biphenyl-4-yl methyl-2-ethoxy-1h-benzo d imidazole-7-carboxylic acid, candesartan ban, 3h candesartan, unii-s8q36md2xx, 2-ethoxy-3-4-2-2h-tetrazol-5-yl phenyl phenyl methyl benzimidazole-4-carboxylic acid, candesartan usan/inn, candesartan usan:inn | |
| HTQMVQVXFRQIKW-UHFFFAOYSA-N | |
| 2-ethoxy-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylic acid | |
| 2541 | |
| 440.45 | |
| Powder |
| 139481-59-7 | |
| White | |
| MFCD00081076 | |
| 14,1739 | |
| Soluble in ethyl acetate,methanol,water (<1mg/ml at 25°C),DMSO (88mg/ml at 25°C),and ethanol (1mg/ml at 25°C). | |
| CCOC1=NC2=CC=CC(=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5)C(=O)O | |
| 440.463 | |
| CHEBI:3347 | |
| 98% |
Chemical Identifiers
| 139481-59-7 | |
| 440.463 | |
| HTQMVQVXFRQIKW-UHFFFAOYSA-N | |
| 2541 | |
| 2-ethoxy-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylic acid |
| C24H20N6O3 | |
| MFCD00081076 | |
| candesartan, blopress, ratacand, 1-2'-1h-tetrazol-5-yl-1,1'-biphenyl-4-yl methyl-2-ethoxy-1h-benzo d imidazole-7-carboxylic acid, candesartan ban, 3h candesartan, unii-s8q36md2xx, 2-ethoxy-3-4-2-2h-tetrazol-5-yl phenyl phenyl methyl benzimidazole-4-carboxylic acid, candesartan usan/inn, candesartan usan:inn | |
| CHEBI:3347 | |
| CCOC1=NC2=CC=CC(=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5)C(=O)O |
Safety and Handling
GHS H Statement
H302-H312-H332-H315-H319-H335
Harmful if swallowed.
Harmful in contact with skin.
Harmful if inhaled.
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.
P201-P202-P281-P308+P313-P501c
H361d
RTECSNumber : DD6671000
TSCA : No
Recommended Storage : Ambient temperatures
RUO – Research Use Only