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Invitrogen™ Calpain S1/S2 Monoclonal Antibody (28F3)
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Catalog No. PIMA134966
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100 μg
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Catalog No. Quantity
PIMA134966 100 μg
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Catalog No. PIMA134966 Supplier Invitrogen™ Supplier No. MA134966
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Description

Mouse Monoclonal Antibody

This antibody specifically recognizes the 28 to 30 kD small subunit of Calpain 1 and Calpain 2 (mu calpain and m calpain). It recognizes both native and denatured protein in ELISA, Western Blot and Immunoprecipitation.

The calpains are calcium-dependent cysteine proteases that are widely expressed in mammalian systems. Both m-calpain (calpain II) and m-calpain (calpain I) are composed of an 80 kD subunit and a 30 kD subunit. Whereas the 30 kDa subunit is shared by both enzymes, the larger catalytic subunits are different and exhibit the distinct Ca++ requirements that are suggested by their names. Whereas m-calpain requires millimolar (mM) levels of calcium, m-calpain is active at micromolar (mM) concentrations of Ca++. In addition to the ubiquitously expressed m- and m- calpains, some tissue-specific calpains have been identified. The calpains appear to serve multiple physiological roles, and ideas concerning the functions of these enzymes are in a state of rapid flux.

Specifications

Antigen Calpain S1/S2
Applications ELISA, Immunoprecipitation, Western Blot
Classification Monoclonal
Clone 28F3
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 3mM sodium azide; pH 7.5
Gene CAPNS1
Gene Accession No. P04632, P13135, Q96L46
Gene Alias 2310005G05Rik; 30K-2; calcium-activated neutral proteinase 2; Calcium-activated neutral proteinase small subunit; Calcium-dependent protease small subunit; Calcium-dependent protease small subunit 1; calcium-dependent protease small subunit 2; calcium-dependent protease, small subunit; calpain 2; calpain 2, (m/II) large subunit; calpain 2, large [catalytic] subunit; calpain 2, large subunit; calpain 4; calpain 4, small subunit (30K); calpain II regulatory subunit; calpain II regulatory subunit (EC 3.4.22.17); calpain large polypeptide L2; Calpain M-type; calpain regulatory subunit; Calpain small subunit 1; calpain small subunit 2; calpain, large polypeptide L2; calpain, small polypeptide; calpain, small subunit 1; calpain, small subunit 2; calpain-2 catalytic subunit; Calpain-2 large subunit; CALPAIN4; CANP; CANP 2; CANP small subunit; CANP2; CANPL2; CANPml; CANPS; Capa4; Capa-4; CAPN2; Capn4; CAPNS; CAPNS1; Capns2; CDPS; CSS1; CSS2; D7Ertd146e; M-calpain; mCANP; Millimolar-calpain
Gene Symbols CAPNS1, CAPNS2
Host Species Mouse
Immunogen Full length protein (Human). Antibody specifically recognizes small subunit.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100300424, 281664, 826, 84290
Target Species Human, Bovine
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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