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Invitrogen™ beta Arrestin 1 Polyclonal Antibody
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Catalog No. PIPA587369
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100 μL
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PIPA587369 100 μL
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Catalog No. PIPA587369 Supplier Invitrogen™ Supplier No. PA587369
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Description

Rabbit Polyclonal Antibody

Positive Samples: A-549, Mouse spleen; Cellular Location: Cell membrane, Cell projection, Cytoplasm, Cytoplasmic vesicle, Membrane, Nucleus, clathrin-coated pit, pseudopodium Immunogen sequence: LASSTLLREG ANREILGIIV SYKVKVKLVV SRGGLLGDLA SSDVAVELPF TLMHPKPKEE PPHREVPENE TPVDTNLIEL DTNDDDIVFE DFARQRLKGM K.

Beta Arrestin 1 is a member of a family of proteins widely expressed but especially abundant in the central nervous system. Serving as an adaptor or scaffold molecule, beta Arrestin 1 is essential for mitogenic signaling and mediates agonist-dependent desensitization and internalization of Gprotein-coupled receptors (GPCRs, e.g., beta 2-adrenergic receptor). After binding to their ligand and interacting with heterotrimeric G proteins, GPCRs are phosphorylated by G-protein receptor kinases (GRKs) on serine residues. Beta Arrestin 1 in the cytosol is phosphorylated by ERK1 and 2 on serine412 in a negative feedback mechanism and binds to the phosphorylated receptors at the plasma membrane. Serine 412 is then dephosphorylated and the GPCRs are internalized, leading to activation of the Ras, Raf, ERK1 and 2 signaling pathway.

Specifications

Antigen beta Arrestin 1
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.63 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene ARRB1
Gene Accession No. P29066, P49407, Q8BWG8
Gene Alias 1200006I17Rik; ARB1; ARR1; ARRB1; ARRB1 protein; arrdc1; arrestin; arrestin 2; arrestin beta 1; arrestin beta-1; arrestin, beta 1; arrestin-2; AW208571; BARRES; beta-arrestin; beta-arrestin1; beta-arrestin-1; G430100A01Rik; Non-visual arrestin-2
Gene Symbols ARRB1
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 300-400 of human beta-arrestin1 (NP_0040322).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 109689, 25387, 408
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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