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Bestatin
CAS: 58970-76-6 | C16H24N2O4 | 308.38 g/mol
$162.86 - $318.56
Chemical Identifiers
| CAS | 58970-76-6 |
|---|---|
| Molecular Formula | C16H24N2O4 |
| Molecular Weight (g/mol) | 308.38 |
| MDL Number | MFCD00083262 |
| InChI Key | VGGGPCQERPFHOB-MCIONIFRSA-N |
| Synonym | bestatin, ubenimex, ubenimexum latin, ubenimex inn:jan, bestatin;ubenimex, s-2-2s,3r-3-amino-2-hydroxy-4-phenylbutanamido-4-methylpentanoic acid, ubenimex bestatin, chembl29292, 2s,3r-3-amino-2-hydroxy-4-phenylbutanoyl-l-leucine, 3-r-amino-2-s-hydroxy-4-phenylbutanoyl-s-leucine |
| PubChem CID | 72172 |
| IUPAC Name | (2S)-2-[[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]amino]-4-methylpentanoic acid |
| SMILES | CC(C)C[C@@H](NC(=O)[C@@H](O)[C@H](N)CC1=CC=CC=C1)C(O)=O |
| Catalog Number | Mfr. No. | Quantity | Price | Quantity | |||||
|---|---|---|---|---|---|---|---|---|---|
| Catalog Number | Mfr. No. | Quantity | Price | Quantity | |||||
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AAJ61106MC
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Thermo Scientific Chemicals
J61106MC |
100 mg |
Each for $162.86
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AAJ61106MD
|
Thermo Scientific Chemicals
J61106MD |
250 mg |
Each for $318.56
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Description
Bestatin can indirectly act on monocytes by inhibiting Aminopeptidase B, which in turn inhibits the catabolism of tuftsin. Bestatin has also been shown to inhibit Leukotriene A4Â hydrolase. It can directly stimulate lymphocytes through its fixation on the cell surface. The agent has been used in multiple leukemia studies. Bestatin is an aminopeptidase inhibitor, inhibits enkephalin metabolism and leukotriene A4 hydrolase. Inhibits tumor cell proliferation.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
ApplicationsBestatin can indirectly act on monocytes by inhibiting Aminopeptidase B, which in turn inhibits the catabolism of tuftsin. Bestatin has also been shown to inhibit Leukotriene A4Â hydrolase. It can directly stimulate lymphocytes through its fixation on the cell surface. The agent has been used in multiple leukemia studies. Bestatin is an aminopeptidase inhibitor, inhibits enkephalin metabolism and leukotriene A4 hydrolase. Inhibits tumor cell proliferation.
Solubility
Soluble in water (<1 25), DMSO (2 mg/ml), methanol (5 mg/ml), 1eq. NaOH (50 mM), ethanol (<1mg/mL at 25°C), acetic acid, aq. HCl, and alkaline solution. Insoluble in ethyl acetate, benzene, hexane, and chloroform.
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.
Chemical Identifiers
| 58970-76-6 | |
| 308.38 | |
| VGGGPCQERPFHOB-MCIONIFRSA-N | |
| 72172 | |
| CC(C)C[C@@H](NC(=O)[C@@H](O)[C@H](N)CC1=CC=CC=C1)C(O)=O |
| C16H24N2O4 | |
| MFCD00083262 | |
| bestatin, ubenimex, ubenimexum latin, ubenimex inn:jan, bestatin;ubenimex, s-2-2s,3r-3-amino-2-hydroxy-4-phenylbutanamido-4-methylpentanoic acid, ubenimex bestatin, chembl29292, 2s,3r-3-amino-2-hydroxy-4-phenylbutanoyl-l-leucine, 3-r-amino-2-s-hydroxy-4-phenylbutanoyl-s-leucine | |
| (2S)-2-[[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]amino]-4-methylpentanoic acid |
Specifications
| 58970-76-6 | |
| White | |
| MFCD00083262 | |
| 14,9842 | |
| Soluble in water (<1 25),DMSO (2mg/ml),methanol (5mg/ml),1eq. NaOH (50 mM),ethanol (<1mg/ml at 25°C),acetic acid,aq. HCl,and alkaline solution. Insoluble in ethyl acetate,benzene,hexane,and chloroform. | |
| CC(C)C[C@@H](NC(=O)[C@@H](O)[C@H](N)CC1=CC=CC=C1)C(O)=O | |
| 308.38 | |
| 308.37 | |
| Bestatin |
| 233°C to 236°C | |
| C16H24N2O4 | |
| 100 mg | |
| bestatin, ubenimex, ubenimexum latin, ubenimex inn:jan, bestatin;ubenimex, s-2-2s,3r-3-amino-2-hydroxy-4-phenylbutanamido-4-methylpentanoic acid, ubenimex bestatin, chembl29292, 2s,3r-3-amino-2-hydroxy-4-phenylbutanoyl-l-leucine, 3-r-amino-2-s-hydroxy-4-phenylbutanoyl-s-leucine | |
| VGGGPCQERPFHOB-MCIONIFRSA-N | |
| (2S)-2-[[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]amino]-4-methylpentanoic acid | |
| 72172 | |
| Powder |
Safety and Handling
P260-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P314-P332+P313-P362-P501c
H315-H319-H335-H373
EINECSNumber : 261-529-2
RTECSNumber : OH2915000
TSCA : No
Recommended Storage : Ambient temperatures
RUO – Research Use Only