BDNF Polyclonal Antibody, Invitrogen™

Description

PA1-18357 detects BDNF from human, mouse and rat samples. PA1-18357 has been successfully used in immunohistochemistry, ELISA , Western blot, and inhibition assay procedures. The PA1-18357 immunogen is recombit human BDNF. Reconstitute with 100 µL of distilled water. Glycerol (1:1) may be added for additional stability.

BDNF (Brain-Derived Neurotrophic Factor) is a member of the neurotrophin family. BDNF is synthesized as pre-proBDNF, followed by cleavage to proBDNF. Although further processing generates the mature, 14 kDa protein, pro-BDNF is biologically active and is secreted in synaptic vesicles along with the mature form. BDNF is widely expressed in the central nervous system and acts in an autocrine and paracrine manner on several classes of neurons. Signaling occurs mainly through the tyrosine kinase receptor TrkB, although binding to the lower-affinity receptor, p75-NTR, has also been demonstrated. BDNF promotes neuronal survival and differentiation and has been shown to play a critical role in memory formation and synaptic regulation. BDNF is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of BDNF is reduced in both Alzheimer′s and Huntington disease patients, and may also play a role in the regulation of stress response and in the biology of mood disorders.