Invitrogen™ B-Raf Monoclonal Antibody (1H12F1, 1H12G10,1F12F11C9)

Description

MA5-15317 targets BRAF in indirect ELISA, IHC and WB applications and shows reactivity with Human samples. The MA5-15317 immunogen is purified recombinant fragment of BRAF expressed in E. Coli.

BRAF is involved in the transduction of mitogenic signals from the cell membrane to the nucleus. It is activated by somatic point mutation in human cancer, and is thought to play a role in the postsynaptic responses of hippocampal neuron. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in B-Raf have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for B-Raf.